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Showing 1–3 of 3 results
Advanced filters: Author: Fabian Henneberg Clear advanced filters

  • Do proteasomes catalyze peptide splicing? Here, the authors develop and apply a method to identify spliced peptides produced from entire proteins, confirm that proteasomes produce a sizeable variety of cis-spliced peptides with well-defined characteristics, and show that non-spliced and spliced peptides are concentrated in hotspots.

    • Wai Tuck Soh
    • Hanna P. Roetschke
    • Michele Mishto
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25

  • The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome.

    • David Haselbach
    • Jil Schrader
    • Holger Stark
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

    • T. Sunn Pedersen
    • M. Otte
    • Sandor Zoletnik
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10