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Showing 1–7 of 7 results
Advanced filters: Author: Fabian Zimmer Clear advanced filters

  • Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

    • Lukas Wettstein
    • Tatjana Weil
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • A neural epigenetic signature detectable via plasma analyses is prognostic in patients with glioblastoma, resembling an oligodendrocyte-progenitor- and neuronal-progenitor-cell-like state and showing increased neuro-to-glioma synapse formation.

    • Richard Drexler
    • Robin Khatri
    • Franz L. Ricklefs
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 1622-1635

  • The mycobacterial ABC transporter IrtAB functions as a siderophore importer despite exhibiting an exporter fold in its structure, and contains a siderophore interaction domain capable of siderophore reduction and iron release inside the cell.

    • Fabian M. Arnold
    • Miriam S. Weber
    • Markus A. Seeger
    Research
    Nature
    Volume: 580, P: 413-417

  • Children are less likely to be infected with SARS-CoV-2 and develop less severe disease than adults, which makes estimation of infection rates challenging. Here, the authors conduct seroprevalence surveys of children in Germany, describe changes in prevalence over time, and identify risk factors for infection.

    • Anna-Lisa Sorg
    • Leon Bergfeld
    • Horst Schroten
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Sex chromosome evolution begins when recombination between a homologous pair of chromosomes is halted. Here, Wright et al.review our current understanding of the causes and mechanisms of recombination suppression between incipient sex chromosomes and suggest future directions for the field.

    • Alison E. Wright
    • Rebecca Dean
    • Judith E. Mank
    ReviewsOpen Access
    Nature Communications
    Volume: 7, P: 1-8