Episomal DNA silencing by Smc5/6 is a three-step process, with the first step involving Smc5/6 binding to and entrapment of the DNA, followed by recruitment of Smc5/6 to promyelocytic leukemia nuclear bodies by SLF2. The third step requires Nse2 but not its SUMO ligase activity.
- Fabien Abdul
- Aurélie Diman
- Michel Strubin