Nature Search

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

The adaptor Nck is known for linking TCR signaling to cytoskeleton regulation. Batista and colleagues show that in B cells, Nck recruits the adaptor BCAP to the BCR to activate the PI(3)K pathway.

Angelo Castello
Mauro Gaya
Facundo D Batista
Research04 Aug 2013
Nature Immunology

Volume: 14, P: 966-975
CD169⁺ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

How and where invariant natural killer T cells encounter glycolipids in vivo remains unclear. Batista and colleagues use multiphoton microscopy to show that CD169⁺ macrophages present lipid antigens to invariant natural killer T cells in lymph nodes.

Patricia Barral
Paolo Polzella
Facundo D Batista
Research14 Mar 2010
Nature Immunology

Volume: 11, P: 303-312
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

Sarah J. Cumbers
Gareth T. Williams
Michael S. Neuberger
Research15 Oct 2002
Nature Biotechnology

Volume: 20, P: 1129-1134
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors

Batista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize the requirements of 10E8 B cell precursors for entry and maturation in the germinal center.

Rashmi Ray
Torben Schiffner
Facundo D. Batista
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1083-1096
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes

A microfluidics- and electron-microscopy-based method enables the characterization of polyclonal antibody responses to infection and vaccination.

Leigh M. Sewall
Rebeca de Paiva Froes Rocha
Andrew B. Ward
ResearchOpen Access03 Jun 2025
Nature Biomedical Engineering

P: 1-14
Correction: Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

Katrina L Randall
Teresa Lambe
Christopher C Goodnow
Amendments and Corrections01 Jul 2010
Nature Immunology

Volume: 11, P: 644
The who, how and where of antigen presentation to B cells

How B cells see antigen has been an area of intense research for many years. Here, recent advances in our understanding of the specific sites, cells and molecules that are involved in the presentation of antigen to B cells are discussed.

Facundo D. Batista
Naomi E. Harwood
Reviews01 Jan 2009
Nature Reviews Immunology

Volume: 9, P: 15-27
CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

David Depoil
Sebastian Fleire
Facundo D Batista
Research02 Dec 2007
Nature Immunology

Volume: 9, P: 63-72
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
B cells acquire antigen from target cells after synapse formation

Facundo D. Batista
Dagmar Iber
Michael S. Neuberger
Research24 May 2001
Nature

Volume: 411, P: 489-494
Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Torben Schiffner
Ivy Phung
William R. Schief
Amendments and CorrectionsOpen Access14 Jun 2024
Nature Immunology

Volume: 25, P: 1307
Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

Invariant NKT cells elicit the rapid release of cytokines. Two papers by Leadbetter and Vinuesa and colleagues show that these cells can also provide direct help to B cells to elicit rapid antibody responses.

Pheh-Ping Chang
Patricia Barral
Carola G Vinuesa
Research27 Nov 2011
Nature Immunology

Volume: 13, P: 35-43
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

High-affinity and isotype-switched antibodies arise from germinal center reactions. Goodnow and colleagues identify the Rho guanine nucleotide–exchange factor DOCK8 as being essential for sustained B cell immune synapse formation in germinal centers and mature antibody responses.

Katrina L Randall
Teresa Lambe
Christopher C Goodnow
Research08 Nov 2009
Nature Immunology

Volume: 10, P: 1283-1291

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Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

CD169⁺ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

Affinity gaps among B cells in germinal centers drive the selection of MPER precursors

Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes

Correction: Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

The who, how and where of antigen presentation to B cells

CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

Vaccination induces broadly neutralizing antibody precursors to HIV gp41

B cells acquire antigen from target cells after synapse formation

Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

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