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Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer

Merghoub, Wolchok and colleagues reveal a role of the extracellular matrix protein thrombospondin-1 (TSP-1) and CD47 in promoting T cell exhaustion during tumor progression in mice and humans.

Chien-Huan Weng
Anais Assouvie
Taha Merghoub
Research17 Nov 2025
Nature Immunology

Volume: 26, P: 2296-2311
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

The cryo-EM structure of a megacomplex between chimeric GPCR, G protein and β-arrestin in their canonical active conformations provides insight into the basis of sustained G protein signaling upon megacomplex internalization.

Anthony H. Nguyen
Alex R. B. Thomsen
Robert J. Lefkowitz
Research18 Nov 2019
Nature Structural & Molecular Biology

Volume: 26, P: 1123-1131

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Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

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