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Showing 1–14 of 14 results
Advanced filters: Author: Falk K Hartmann Clear advanced filters

  • The endoribonuclease PUCH, a trimer of Schlafen-like-domain proteins, initiates piRNA processing in the nematode Caenorhabditis elegans through 5′-end piRNA precursor cleavage.

    • Nadezda Podvalnaya
    • Alfred W. Bronkhorst
    • René F. Ketting
    ResearchOpen Access
    Nature
    Volume: 622, P: 402-409

  • This study reports adhibin, a synthetic carbazole that suppresses the migratory and adhesive properties of cancer cells by a mechanism of targeted RhoGAP class-IX myosin inhibition and selective RhoGTPase interference, both translating into migrastatic activity, opening other perspectives in cancer therapy and basic research.

    • Despoina Kyriazi
    • Lea Voth
    • Georgios Tsiavaliaris
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25

  • Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways involved, and show that DMF suppresses Tc17 pathogenicity in a mouse model of MS.

    • Christina Lückel
    • Felix Picard
    • Magdalena Huber
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune checkpoint inhibition in cancer.

    • Ignacio Melero
    • Maria de Miguel Luken
    • Eugen Leo
    ResearchOpen Access
    Nature
    Volume: 637, P: 1218-1227

  • Myosins have roles in many biological processes that go beyond muscle contraction and vesicle transport, including furrowing during cytokinesis, signal transduction and RNA polymerase I–dependent transcription. Studying these various complex processes will require the use of isoform-specific small molecules that alter motor activity. The marine natural product pentabromopseudilin is now shown to act as an allosteric effector of myosin function and potent inhibitor of vertebrate myosin-5a–dependent motor activity.

    • Roman Fedorov
    • Markus Böhl
    • Dietmar J Manstein
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 80-88

  • Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

    • Tirtha Chanda
    • Sarah Haggenmueller
    • Titus J. Brinker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Artificial intelligence has become popular as a cancer classification tool, but there is distrust of such systems due to their lack of transparency. Here, the authors develop an explainable AI system which produces text- and region-based explanations alongside its classifications which was assessed using clinicians’ diagnostic accuracy, diagnostic confidence, and their trust in the system.

    • Tirtha Chanda
    • Katja Hauser
    • Titus J. Brinker
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

    • Colm O'Dushlaine
    • Lizzy Rossin
    • Gerome Breen
    Research
    Nature Neuroscience
    Volume: 18, P: 199-209

  • Li+-selective solid electrolytes may enable next-generation battery systems, such as Li–S and Li–O2. Now, in an exemplar system, it is shown that a resistive interphase forms at the interface between solid and liquid electrolytes, termed the solid-liquid electrolyte interphase (SLEI). An in situ study of this undesirable effect is supported by state-of-the-art surface analysis.

    • Martin R. Busche
    • Thomas Drossel
    • Jürgen Janek
    Research
    Nature Chemistry
    Volume: 8, P: 426-434

  • Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

    • S Hong Lee
    • Stephan Ripke
    • Naomi R Wray
    Research
    Nature Genetics
    Volume: 45, P: 984-994