During development, wound healing, differentiation or cancer metastasis, cells move continuously in heterogeneous environments, hence understanding how cell migration is controlled by confinement and by different substrate shapes is crucial to begin to build a first conceptual framework for cell motility. Here the authors develop a computational approach to systematically investigate the effect that a complex environment has on cell motion and speed.
- Benjamin Winkler
- Igor S. Aranson
- Falko Ziebert