Deficiency of the X-linked SHL gene GPRASP2 causes hearing loss and depression-like behaviors in mice. Mechanistically, GPRASP2 binds to NCAM1; its depletion promotes ferritinophagy via NCAM1 downregulation, inducing ferroptosis in OHCs.
- Yajie Lu
- Fanghong Sheng
- Tianming Wang