Previously, the opioid analgesic drug JCT801 was reported to induce cell death via disruption of pH homeostasis in pancreatic cancer cells. Here, the authors investigate the metabolic mechanisms underlying JCT801-induced cell death, identifying cholesterol synthesis gene, CYP51A1, as a suppressor of alkalization-induced cell death.
- Fangquan Chen
- Hu Tang
- Jiao Liu
