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Showing 1–3 of 3 results
Advanced filters: Author: Felicia Liu-Fei Clear advanced filters

  • As the coronavirus disease 2019 (COVID-19) pandemic evolves, evidence has implicated the heart as a critical target of injury. We examined purported mechanisms of COVID-19-associated heart damage in 21 COVID-19-positive decedents, compared to clinically matched controls and other etiologies of viral myocarditis in a custom tissue microarray, via immunohistochemistry and in situ hybridization. Collectively, COVID-19-associated cardiac injury was multifactorial, with elevated levels of neutrophil extracellular traps and von Willebrand factor as defining features of direct and indirect viral-associated injury.

    • Paul J. Hanson
    • Felicia Liu-Fei
    • Bruce M. McManus
    Research
    Laboratory Investigation
    Volume: 102, P: 814-825

  • The prevalence and contribution of viruses to heart failure phenotypes are increasingly recognized, while still underappreciated and underreported. We designed a tissue microarray with cardiac muscle tissue from 78 heart failure patients and probed for common cardiotropic viruses via in situ hybridization. Viral RNA was detected in 46.4% of patients, higher than anticipated for these heart failure conditions that include those not previously associated with a viral trigger or an exacerbating role.

    • Paul J. Hanson
    • Felicia Liu-Fei
    • Bruce M. McManus
    Research
    Laboratory Investigation
    Volume: 102, P: 14-24