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Showing 1–6 of 6 results
Advanced filters: Author: Felipe Cortés-Ledesma Clear advanced filters

  • DNA can be repaired by two different mechanisms, depending on whether a homologous template is available. Thus, homologous recombination is restricted to S and G2 phases of the cell cycle. The activity of cyclin-dependent kinases (CDKs) is also cell cycle regulated, and the yeast CDK Cdc28 controls DNA resection, an early step of homologous recombination. This work shows that the target of Cdc28 in regulating DNA resection is Sae2.

    • Pablo Huertas
    • Felipe Cortés-Ledesma
    • Stephen P. Jackson
    Research
    Nature
    Volume: 455, P: 689-692

  • The role of ATM in DNA double-strand break (DSB) signalling is well established, but its function in the repair process remains controversial. Here, Álvarez-Quilón et al.show that ATM acts in the joining of blocked DSBs, uncovering DNA end structure as a key factor determining ATM involvement in DSB repair.

    • Alejandro Álvarez-Quilón
    • Almudena Serrano-Benítez
    • Felipe Cortés-Ledesma
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2−/− Atm−/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours.

    • Alejandro Álvarez-Quilón
    • José Terrón-Bautista
    • Felipe Cortés-Ledesma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia in mice.

    • Weijun Feng
    • Daisuke Kawauchi
    • Hai-Kun Liu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Keith Caldecott, Bert de Vries, Sherif El-Khamisy, Gianpiero Cavalleri and colleagues identify homozygous TDP2 mutations in individuals with intellectual disability, seizures and ataxia. Their follow-up studies suggest that TDP2 is required to maintain normal transcription in response to the DNA double-strand breaks induced by abortive TOP2 activity.

    • Fernando Gómez-Herreros
    • Janneke H M Schuurs-Hoeijmakers
    • Keith W Caldecott
    Research
    Nature Genetics
    Volume: 46, P: 516-521