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Showing 1–4 of 4 results
Advanced filters: Author: Felix Freuler Clear advanced filters

  • In this paper, Mutlu et al. identifies a STING degrader, AK59, which inhibits downstream cGAS/STING activity through STING degradation employing a HECT-domain E3 ligase HERC4 and proteasomal ubiquitination pathway.

    • Merve Mutlu
    • Isabel Schmidt
    • Danilo Guerini
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Interleukin-1β is a pro-inflammatory cytokine of medical importance. Here the authors describe the discovery of a low-molecular weight compound that antagonizes hIL-1β function in cells, demonstrating the relevance of this discovery for future development of hIL-1β directed therapeutics.

    • Ulrich Hommel
    • Konstanze Hurth
    • Frédéric Bornancin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.

    • Melusine Bleu
    • Fanny Mermet-Meillon
    • Giorgio Giacomo Galli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • High-resolution crystal structures of the rat succinate receptor SUCNR1 in an inactive confirmation, and the humanized rat SUCNR1 bound to an antagonist, provide insights into the structure of these receptors and the species selectivity of antagonist binding.

    • Matthias Haffke
    • Dominique Fehlmann
    • Veli-Pekka Jaakola
    Research
    Nature
    Volume: 574, P: 581-585