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Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Increasing the speed of magnetization switching is an obvious pathway to improve spintronic device performance. However, very fast magnetization switching is accompanied by instabilities. Here, Gidding et al study these instabilities using optical pumping, and show that instability generated spin-waves can achieve a high enough amplitude to drive switching of the magnetization, with a distinctive coherent pattern.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Resonant excitation of phonons by a laser pulse switches the magnetization of a thin yttrium iron garnet film. This particular combination of longitudinal optical phonons results in a quadrupolar pattern, but this could be tailored in the future.

Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new regulator of AR stability and function in prostate cancer.

Spin-to-charge interconversion is a foundational requirement for spin-based electronics. Herein, Victor et al explore spin-pumping in MoS₂, and reveal two spin-pumping channels arising from the metallic edge and semiconducting bulk respectively.

Ferrimagnetic Gd₄₄Co₅₆ near the compensation temperature enables domain wall motion with a speed of 1.3 km s^–1 and room temperature skyrmions with diameters close to 10 nm.

The authors computationally and experimentally derive the selection rules on polarization, wavelengths, and magnetic damping for non-dissipative аll-optical magnetic recording with femtosecond laser pulses in Co-doped garnet film. The suggested approach is based on a multiple resonant pumping of localized d-electron transitions.

Magnetic domain walls could form the basis for information technology with high storage density, but require comparatively high current densities to be moved by spin torque. Here, the authors demonstrate a radically different approach with perpendicular magnetic field pulses moving domain walls synchronously.

It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.

On the basis of encouraging preclinical activity, an anti-CEACAM5 antibody–drug conjugate with a topoisomerase 1 inhibitor payload is being tested in an ongoing phase 1 trial where recommended doses for further testing have been identified and an unconfirmed overall response rate of 15% was observed in patients with metastatic colorectal cancer.

Electrical manipulation of antiferromagnetic order is crucial for future memory devices, but existing switching schemes require a large current density. Here, the authors achieve record low current density switching in FeRh by taking advantage of its antiferromagnetic to ferromagnetic phase transition.

Time-resolved X-ray scattering is utilized to demonstrate an ultrafast 300 ps topological phase transition to a skyrmionic phase. This transition is enabled by the formation of a transient topological fluctuation state.

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

The polarization direction of a ferroelectric-like state can be used to control the conversion of spin currents into charge currents at the surface of strontium titanate, a non-magnetic oxide.

Expanding the scope of materials for spin caloritronics enhances the opportunity to achieve more energy efficient memory and sensor devices. Here the authors report the tunnel magneto-Seebeck effects in magnetic tunnel junctions with Co₂FeAl and Co₂FeSi Heusler compounds.

A very large spin-to-charge conversion arising from a combination of the Rashba effect and topologically non-trivial states is realized at the interface of strontium titanate and aluminium, with implications for the role of topology in memory and transistor designs.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

The deterministic nucleation of single skyrmions at a controlled position along multilayered magnetic racetracks is demonstrated by exploiting spin-orbit torques without the need of in-plane magnetic fields.

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

Compared to electromagnetic waves, the wavelength of spin waves is significantly shorter at gigahertz frequencies, enabling the miniaturisation of wave-based devices. Here, the authors present a magnonic Fabry-Pérot resonator allowing for nanoscale and reconfigurable manipulation of spin waves.

A genome-wide collection of N-terminally tagged yeast libraries allows easy swapping of tags and exploration of the yeast proteome.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

The mechanism responsible for the toughness of nacre, the hierarchical iridescent material in seashells, is still unknown. Espinosa and colleagues show that the waviness of its tablets leads to interfacial hardening, and ultimately to energy dissipation, when the material is stressed.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Whole-genome bisulfite sequencing along with whole-genome and transcriptome sequencing of 100 prostate cancer metastases identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype.

The Joule heating free magnon spintronics advances conventional electronics but demands more magnon-based logic operations. Here the authors achieved the magnon spin valve functionality in a YIG/CoO/Co structure where the amplitude of transmitted magnon from the YIG layer is dependent on the relative alignment of the YIG and Co magnetization.

Experiments show that when driven by electric currents, magnetic skyrmions experience transverse motion due to their topological charge — similar to the conventional Hall effect experienced by charged particles in a perpendicular magnetic field.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

Here, the authors generate a single-cell DNA methylation and transcriptome dataset from mouse peripheral blood samples, spanning a broad range of ages. They next develop scEpiAge, a single-cell DNA methylation age predictor.

Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes. The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities.

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally only trigger wound healing can activate regeneration of heads and bones.

A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.

A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.

In prostate cancer, investigating aberrant gene expression may shed light on disease etiology. Here, the authors imputed expression transcriptome-wide for 233,955 European ancestry men, discovering and replicating the associations between prostatic expression for select genes and prostate cancer risk, including the highly prevalent gene fusion partner TMPRSS2. The authors furthermore integrate diverse functional genomic datasets to interpret the epigenetic mechanisms by which the implicated risk variants and genes modulate disease risk.

By comparing neural responses to diverse visual stimuli measured with a standardized two-photon imaging pipeline, the authors reveal response specializations within the mouse visual cortex.