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Showing 1–11 of 11 results
Advanced filters: Author: Felix Lasitschka Clear advanced filters

  • Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.

    • Partha Dutta
    • Gabriel Courties
    • Matthias Nahrendorf
    Research
    Nature
    Volume: 487, P: 325-329

  • Glucose and its metabolic derivatives are increased the plasma of patients with diabetes. Peter Nawroth and colleagues demonstrate that one such metabolite, methylglyoxal, is increased in patients with painful diabetic neuropathy, and find that it acts by modifying the excitability characteristics of a sodium channel protein.

    • Angelika Bierhaus
    • Thomas Fleming
    • Peter P Nawroth
    Research
    Nature Medicine
    Volume: 18, P: 926-933

  • Arteries are colonized by macrophages of multiple origins, derived prenatally from the yolk sac and during an early postnatal wave from the bone marrow. During sepsis, blood monocyte-derived macrophages transiently contribute to, but do not replace, resident arterial macrophages that largely self-renew in situ.

    • Kay Klapproth
    • Felix Lasitschka
    • Hans-Reimer Rodewald
    News & Views
    Nature Immunology
    Volume: 17, P: 117-118

  • T cells develop from thymic precursor cells that are constantly replaced with newly arriving bone marrow progenitor cells, and the ‘old’ and ‘new’ cells are shown here to compete; in the absence of cell competition, when the influx of new bone marrow progenitor cells is blocked, the old cells acquire the ability to self-renew and eventually become transformed, leading to the development of a form of leukaemia.

    • Vera C. Martins
    • Katrin Busch
    • Hans-Reimer Rodewald
    Research
    Nature
    Volume: 509, P: 465-470

  • Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.

    • Marek Cyrklaff
    • Sirikamol Srismith
    • Michael Lanzer
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Carbohydrate-specific antibodies are typically thought to be of low affinity and produced by T cell–independent pathways. Wardemann and colleagues identify human memory B cells that can produce specific ‘affinity-matured’ antibodies to the O antigen of Klebsiella lipopolysaccharides.

    • Tim Rollenske
    • Valeria Szijarto
    • Hedda Wardemann
    Research
    Nature Immunology
    Volume: 19, P: 617-624

  • A property of oncogene-induced senescence (OIS) is the induction of a secretory phenotype, termed the senescence-associated secretome (SASP). Gil and colleagues now provide evidence that senescence can be transmitted in a paracrine manner, by showing that induction of the SASP in cells undergoing OIS by inflammasome-mediated interleukin-1 signalling can promote senescence of normal neighbouring cells.

    • Juan Carlos Acosta
    • Ana Banito
    • Jesús Gil
    Research
    Nature Cell Biology
    Volume: 15, P: 978-990

  • Resting CD4+ T cells are resistant to HIV-1 infection, but the underlying reasons for this lack of permissiveness have not been clear. Oliver Fackler and colleagues now report that SAMHD1, the deoxynucleoside triphosphate triphosphohydrolase responsible for restriction of HIV-1 infection in myeloid cells, also restricts infection of resting CD4+ T cells. The findings shed new light on the mechanisms of cellular and molecular regulation of HIV-1 infection.

    • Hanna-Mari Baldauf
    • Xiaoyu Pan
    • Oliver T Keppler
    Research
    Nature Medicine
    Volume: 18, P: 1682-1688