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Showing 1–5 of 5 results
Advanced filters: Author: Felix R. M. Beinlich Clear advanced filters

  • l-Lactate is increasingly recognized as a key metabolite and signalling molecule in mammals, but the methods to investigate it in vivo have been limited. Here, authors report a pair of improved biosensors—one green and one red—for visualizing l-lactate both inside and outside of cells.

    • Yusuke Nasu
    • Abhi Aggarwal
    • Robert E. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure, and find that crowdsourcing model-building works.

    • Scott Horowitz
    • Brian Koepnick
    • James C. A. Bardwell
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Astrocytes act as a dynamic Cl− reservoir regulating Cl− homeostasis in the CNS. Astrocytic Cl− is high and stable during sleep, it is lower during wakefulness and fluctuates in response to sensory input and motor activity. Efflux of Cl− from astrocytes supports inhibitory transmission in the CNS.

    • Verena Untiet
    • Felix R. M. Beinlich
    • Maiken Nedergaard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Holstein-Rønsbo et al. show that functional hyperemia increases glymphatic CSF inflow and clearance. Direct stimulation of vascular smooth muscle cells, in the absence of neuronal activation, similarly enhances glymphatic flow.

    • Stephanie Holstein-Rønsbo
    • Yiming Gan
    • Maiken Nedergaard
    Research
    Nature Neuroscience
    Volume: 26, P: 1042-1053