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Showing 1–2 of 2 results
Advanced filters: Author: Feng-wei Tan Clear advanced filters

  • Depletion of tribbles pseudokinase 3 (TRIB3) is known to suppress the expression of several tumor-promoting factors, including EGFR. Here, the authors show that TRIB3 interacts with EGFR and regulates its stability and activity, and perturbing EGFR-TRIB3 interaction attenuates NSCLC progression by accelerating EGFR degradation.

    • Jiao-jiao Yu
    • Dan-dan Zhou
    • Zhuo-Wei Hu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Jie He and colleagues report exome sequencing of 113 tumor-normal pairs of esophageal squamous cell carcinoma. They highlight mutations in genes involved in cell cycle and apoptosis regulation, histone modifier genes and genes encoding members of the Hippo and Notch pathways.

    • Yi-Bo Gao
    • Zhao-Li Chen
    • Jie He
    Research
    Nature Genetics
    Volume: 46, P: 1097-1102