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Showing 1–3 of 3 results
Advanced filters: Author: Fergil Mills Clear advanced filters

  • Drugs of abuse alter the strength of synaptic connections within the mesocorticolimbic dopamine system. The current study demonstrates that this is dependent on the recruitment of cadherin to the synaptic membrane. Increased cadherin at dopaminergic synapses impairs cocaine-induced synaptic plasticity, resulting in a reduction in cocaine preference.

    • Fergil Mills
    • Andrea K Globa
    • Shernaz X Bamji
    Research
    Nature Neuroscience
    Volume: 20, P: 540-549

  • In this issue of Nature Neuroscience, Menegas et al. demonstrate a role for midbrain dopamine neurons projecting to the tail of the striatum in encoding stimulus novelty and threat avoidance. From this study emerges a model whereby distinct dopaminergic projections to striatum influence behavior along at least two axes, one representing value and one representing threat.

    • Cody A. Siciliano
    • Fergil Mills
    • Kay M. Tye
    News & Views
    Nature Neuroscience
    Volume: 21, P: 1296-1297