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Showing 1–2 of 2 results
Advanced filters: Author: Ferzin Sethna Clear advanced filters
  • Qi Ding, Ferzin Sethna et al. perform a computational analysis of the transcriptome profile of Fmr1−/− neurons and identify trifluoperazine as potential therapeutic agent against Fragile X Syndrome. Next, they show that low doses of trifluoperazine ameliorate some of the behavioral and molecular phenotypes present in Fmr1−/− mice.

    • Qi Ding
    • Ferzin Sethna
    • Hongbing Wang
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13
  • Fragile X syndrome (FXS) is a leading cause of autism and neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, the authors show that neurons from Fmr1 knockout mice have increased levels of ADCY1 protein, producing abnormal ERK1/2 signalling, dysregulated protein synthesis and behavioural symptoms associated with FXS.

    • Ferzin Sethna
    • Wei Feng
    • Hongbing Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11