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Showing 1–50 of 60 results

Advanced filters: Author: Finn C. Nielsen Clear advanced filters

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

Finn C. Nielsen
Lars Østergaard
Jan Christiansen
Research28 Sept 1995
Nature

Volume: 377, P: 358-362
Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes

Jan Kalbitzer
David Erritzoe
Gitte Knudsen
ResearchOpen Access10 Sept 2008
Nature Precedings

P: 1
The quality of COPD care in general practice in Denmark: the KVASIMODO Study

Peter Lange
Finn Vejlø Rasmussen
Lill Moll Nielsen
Research21 May 2007
Primary Care Respiratory Journal

Volume: 16, P: 174-181
Photochemically-enabled, post-translational production of C-terminal amides

C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here, the authors report a straightforward and scalable approach to the C-terminal α-amidation of peptides and proteins from cysteine-extended polypeptide precursors.

David Hymel
Felix Wojcik
Michael R. Harris
ResearchOpen Access30 Nov 2024
Nature Communications

Volume: 15, P: 1-8
The Cretaceous-Tertiary boundary event

Finn Surlyk
News & Views22 May 1980
Nature

Volume: 285, P: 187-188
Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

Hanne B. Rasmussen
Sven Branner
Nicolai Wagtmann
Research16 Dec 2002
Nature Structural Biology

Volume: 10, P: 19-25
Peculiar transient behaviors of organic electrochemical transistors governed by ion injection directionality

Few studies have investigated the structural properties of organic mixed ionic-electronic conductors in relation to the transient device characteristics. Here, Kim et al. show that backbone-dependent molecular orientation affects ion injection directionality, which determines ion mobility and transient response.

Ji Hwan Kim
Roman Halaksa
Myung-Han Yoon
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Retraction Note: A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA

Mohsen Mohammadniaei
Ming Zhang
Yi Sun
Amendments and CorrectionsOpen Access17 May 2025
Nature Communications

Volume: 16, P: 1
Ancient human genome sequence of an extinct Palaeo-Eskimo

The first genome sequence of an ancient human is reported. It comes from an approximately 4,000-year-old permafrost-preserved hair from a male from the first known culture to settle in Greenland. Functional single-nucleotide polymorphism (SNP) assessment is used to assign possible phenotypic characteristics and high-confidence SNPs are compared to those of contemporary populations to find those most closely related to the individual.

Morten Rasmussen
Yingrui Li
Eske Willerslev
ResearchOpen Access11 Feb 2010
Nature

Volume: 463, P: 757-762
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Blood Volume as a new functional image-based biomarker of progression in metastatic renal cell carcinoma

Aska Drljevic-Nielsen
Finn Rasmussen
Frede Donskov
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Structure of HBP, a multifunctional protein with a serine proteinase fold

The structure of human heparin binding protein reveals that the serine proteinase fold has been used as a scaffold for a multifunctional protein with antibacterial activity, monocyte and T-cell activating properties and endotoxin and heparin binding capacity.

Lars Fogh Iversen
Jette Sandholm Kastrup
Ingrid Kjøller Larsen
Correspondence01 Apr 1997
Nature Structural Biology

Volume: 4, P: 265-268
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
RETRACTED ARTICLE: A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA

The reliance on enzymes in SARS-CoV-2 RNA detection imposes limits on transport and storage conditions. Here the authors use non-enzymatic isothermal amplification to detect RNA with no need for reverse transcription.

Mohsen Mohammadniaei
Ming Zhang
Yi Sun
ResearchOpen Access24 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.

Manuel A. Ferreira
Eric R. Gamazon
Georgia Chenevix-Trench
ResearchOpen Access15 Apr 2019
Nature Communications

Volume: 10, P: 1-18
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

Richard J Pietras
Mark D Pegram
Dennis J Slamon
Research29 Oct 1998
Oncogene

Volume: 17, P: 2235-2249
Functional characterization of BRCA1 gene variants by mini-gene splicing assay

Ane Y Steffensen
Mette Dandanell
Thomas vO Hansen
ResearchOpen Access26 Mar 2014
European Journal of Human Genetics

Volume: 22, P: 1362-1368
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Establishing the relative transmissibility of emerging variants of SARS-CoV-2 is key for pandemic management. Here, the authors use full-population administrative data from Denmark linked to PCR test results and estimate that the Alpha variant was ~60% higher than other strains circulating in early 2021.

Frederik Plesner Lyngse
Kåre Mølbak
Carsten Thure Kirkeby
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-8
De novo mutations in familial adenomatous polyposis (FAP)

Rasmus Ripa
Marie Luise Bisgaard
Finn Cilius Nielsen
Research02 Oct 2002
European Journal of Human Genetics

Volume: 10, P: 631-637
Metabolic syndrome in women with previous gestational diabetes

Karsten Kaiser
Michael Festersen Nielsen
Finn Friis Lauszus
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Averting biodiversity collapse in tropical forest protected areas

Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

William F. Laurance
D. Carolina Useche
Franky Zamzani
Research25 Jul 2012
Nature

Volume: 489, P: 290-294
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Haoyu Zhang
Thomas U. Ahearn
Montserrat García-Closas
Research18 May 2020
Nature Genetics

Volume: 52, P: 572-581
Plasma total cell-free DNA is a prognostic biomarker of overall survival in metastatic solid tumour patients

Ida Viller Tuxen
Lise Barlebo Ahlborn
Ulrik Lassen
ResearchOpen Access12 Jun 2019
British Journal of Cancer

Volume: 121, P: 125-130
Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

Rasmus J. N. Frandsen
Paiman Khorsand-Jamal
Uffe H. Mortensen
ResearchOpen Access27 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

Genome-wide association studies in combination with functional analyses identify a genetic variant that explains why anti-tumour necrosis factor therapy, used in several autoimmune diseases, exacerbates multiple sclerosis.

Adam P. Gregory
Calliope A. Dendrou
Lars Fugger
Research08 Jul 2012
Nature

Volume: 488, P: 508-511
Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access14 Jan 2022
European Journal of Human Genetics

Volume: 30, P: 349-362
Family history of cancer and the risk of childhood solid tumours: a Norwegian nationwide register-based cohort study

Ruby Del Risco Kollerud
Karl Gerhard Blaasaas
Øyvind Næss
ResearchOpen Access20 Feb 2018
British Journal of Cancer

Volume: 118, P: 905-912
Hereditary breast and ovarian cancer: new genes in confined pathways

This Review summarizes our current understanding of the functions of established and emerging hereditary breast and ovarian cancer genes in genome maintenance pathways. The authors discuss how classifying variants as pathogenic by structural and functional analysis will aid clinical management.

Finn Cilius Nielsen
Thomas van Overeem Hansen
Claus Storgaard Sørensen
Reviews12 Aug 2016
Nature Reviews Cancer

Volume: 16, P: 599-612
The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO)

Cecilia Margareta Lund
Kirsten Kjeldgaard Vistisen
Dorte Lisbeth Nielsen
ResearchOpen Access07 Apr 2021
British Journal of Cancer

Volume: 124, P: 1949-1958
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers. They identify a locus at 19p13 associated with breast cancer risk in BRCA1 mutation carriers, and further replication studies identify this locus as associated with estrogen receptor–negative breast cancer in the general population.

Antonis C Antoniou
Xianshu Wang
Fergus J Couch
Research19 Sept 2010
Nature Genetics

Volume: 42, P: 885-892
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA

Finn Cilius Nielsen
Anne Charlotte Jäger
Lene Juel Rasmussen
Research15 Dec 2003
Oncogene

Volume: 23, P: 1457-1468
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLα and hMLH1–hEXO1 complexes

Anne Charlotte Jäger
Merete Rasmussen
Lene Juel Rasmussen
Research27 Jun 2001
Oncogene

Volume: 20, P: 3590-3595
High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Birgitte Bertelsen
Ida Viller Tuxen
Finn Cilius Nielsen
ResearchOpen Access21 Jun 2019
npj Genomic Medicine

Volume: 4, P: 1-11
Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Xia Jiang
Hilary K. Finucane
Sara Lindström
Amendments and CorrectionsOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-8
Gestational Protein Restriction in Mice Has Pronounced Effects on Gene Expression in Newborn Offspring's Liver and Skeletal Muscle; Protective Effect of Taurine

Ole Hartvig Mortensen
Hanne Lodberg Olsen
Bjørn Quistorff
Research01 Jan 2010
Pediatric Research

Volume: 67, P: 47-53
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
Efficient Grafting of Cyclodextrin to Alginate and Performance of the Hydrogel for Release of Model Drug

Line Aa. Omtvedt
Marianne Ø. Dalheim
Finn L. Aachmann
ResearchOpen Access27 Jun 2019
Scientific Reports

Volume: 9, P: 1-11
On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

Nancy Hamel
Bing-Jian Feng
William D Foulkes
Research01 Dec 2010
European Journal of Human Genetics

Volume: 19, P: 300-306
CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

Torben Sølbeck Rasmussen
Anna Kirstine Koefoed
Dennis Sandris Nielsen
Research11 Jan 2023
The ISME Journal

Volume: 17, P: 432-442
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Denise G. O’Mahony
Susan J. Ramus
Elizabeth Santana dos Santos
ResearchOpen Access19 Apr 2023
British Journal of Cancer

Volume: 128, P: 2283-2294
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R. Barnes
Matti A. Rookus
Antonis C. Antoniou
ResearchOpen Access15 Jul 2020
Genetics in Medicine

Volume: 22, P: 1653-1666
CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

Maria L. Elkjaer
Arkadiusz Nawrocki
Zsolt Illes
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

Frank Qian
Matti A. Rookus
Dezheng Huo
ResearchOpen Access19 Jun 2019
British Journal of Cancer

Volume: 121, P: 180-192
Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

Karri Silventoinen
Weilong Li
Jaakko Kaprio
ResearchOpen Access09 Aug 2022
International Journal of Obesity

Volume: 46, P: 1901-1909
Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy

Chrysoula Dimopoulou
Jens D. Lundgren
Rasmus L. Marvig
Research23 Dec 2019
Journal of Human Genetics

Volume: 65, P: 325-335
Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice

Merete Ellekilde
Ellika Selfjord
Camilla H. F. Hansen
ResearchOpen Access01 Aug 2014
Scientific Reports

Volume: 4, P: 1-8

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