Kyriakopoulou et al. report that adeno-associated virus-mediated delivery of PKP2 in PKP2c.2013delC/WT induced pluripotent stem cell-derived cardiomyocytes and heterozygous Pkp2c.1755delA knock-in mice restores cardiomyocyte junctions, enhances cardiac function and mitigates arrhythmogenic substrates leading to arrhythmogenic cardiomyopathy.
- Eirini Kyriakopoulou
- Danielle Versteeg
- Eva van Rooij
