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Showing 1–2 of 2 results
Advanced filters: Author: Florian Schlauderer Clear advanced filters

  • The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.

    • Florian Schlauderer
    • Thomas Seeholzer
    • Katja Lammens
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The Mre11–Rad50–Nbs1 (MRN) complex plays a central role in DNA damage signaling. The crystal structures of the Schizosaccharomyces pombe Mre11 catalytic domain in its apo form and in complex with a fragment of Nbs1 are now reported. Along with functional analyses, the work provides insight into checkpoint signaling and ATM activation as well as a framework to understand disease-related mutations.

    • Christian B Schiller
    • Katja Lammens
    • Karl-Peter Hopfner
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 693-700