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Indicators of different outcomes after prolonged weaning

Julia D. Michels-Zetsche
Evelyn Röser
Franziska C. Trudzinski
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

The signalling cascade involved in lung ischaemia–reperfusion-induced oedema is poorly understood. Using knockout mice, Weissmannet al. propose a model in which reactive oxygen species production by endothelial NOX2 leads to phospholipase C-γ activation, DAG kinase inhibition and subsequent TRPC6 activation.

Norbert Weissmann
Akylbek Sydykov
Alexander Dietrich
ResearchOpen Access31 Jan 2012
Nature Communications

Volume: 3, P: 1-10
MCM double hexamer loading visualized with human proteins

Biochemical and structural studies of the human MCM replicative DNA helicase complex show differences from the yeast complex and provide insights into mechanisms of double hexamer assembly on sequence-independent replication origins.

Florian Weissmann
Julia F. Greiwe
Alessandro Costa
ResearchOpen Access27 Nov 2024
Nature

Volume: 636, P: 499-508
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

The cell cycle regulatory E3 ligase APC/C cooperates with UBE2C to prime substrates with ubiquitin and UBE2S to extend the ubiquitin chains. Careful analysis reveals that binding of the UBE2S to APC/C accelerates the rate-limiting step of APC/C–UBE2C.

Raquel C. Martinez-Chacin
Tatyana Bodrug
Nicholas G. Brown
Research11 May 2020
Nature Structural & Molecular Biology

Volume: 27, P: 550-560
MRI distortion correction is associated with improved local control in stereotactic radiotherapy for brain metastases

Daniel Höfler
Johanna Grigo
Florian Putz
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-11

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Indicators of different outcomes after prolonged weaning

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

MCM double hexamer loading visualized with human proteins

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

MRI distortion correction is associated with improved local control in stereotactic radiotherapy for brain metastases

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