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Advanced filters: Author: Florian Zwolanek Clear advanced filters

Inhibition of CBLB protects from lethal Candida albicans sepsis

Wirnsberger et al. report that an E3 ubiquitin ligase, CBLB, impairs immune control of Candida albicans and that targeting CBLB protects mice from lethal fungal infection.

Gerald Wirnsberger
Florian Zwolanek
Josef M Penninger
Research18 Jul 2016
Nature Medicine

Volume: 22, P: 915-923
Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

Josef Penninger and colleagues generate mice with conditional knockout of Jagn1 in hematopoietic cells. They show that the mice have a defective neutrophil-mediated immune response to Candida albicans, and GM-CSF treatment restored the defective fungicidal activity.

Gerald Wirnsberger
Florian Zwolanek
Josef M Penninger
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 1028-1033
The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways

Raju Shivarathri
Michael Tscherner
Karl Kuchler
ResearchOpen Access01 Jul 2019
Scientific Reports

Volume: 9, P: 1-18