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Showing 1–3 of 3 results
Advanced filters: Author: Fotis Nikolos Clear advanced filters

  • Zhang, Chen, and colleagues present Thor, a platform that turns spot-level spatial transcriptomics into single-cell gene maps using the paired histology image, without using single-cell RNA-seq data. Thor unveils fine tissue architectures, and it expands our knowledge on fibrosis and vascular-regenerative gene expression.

    • Pengzhi Zhang
    • Weiqing Chen
    • Guangyu Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Chemoimmunotherapy recently failed to improve objective response for patients with advanced muscle-invasive bladder cancer (MIBC). Here using two murine models of immune-excluded MIBC, the authors show that resistance to chemoimmunotherapy can be overcome by blocking the COX-2/prostaglandin E2 axis, reinvigorating anti-tumor immune responses.

    • Fotis Nikolos
    • Kazukuni Hayashi
    • Keith Syson Chan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

    • Yu-Cheng Lee
    • Antonina V. Kurtova
    • Keith Syson Chan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16