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The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active

Targeting histone deacetylases (HDACs) alone has shown limited success in solid tumours. Here, authors report that the HDAC1/2 inhibitor romidepsin confers responsiveness to receptor tyrosine kinase inhibitors, with enhanced therapeutic effects in models of hepatocellular carcinoma, leading to tumour regression and an immune-stimulatory profile.

Celia Sequera
Margherita Grattarola
Flavio Maina
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-26
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure.

Zakaria Ezzoukhry
Elodie Henriet
Frédéric Saltel
ResearchOpen Access23 May 2018
Nature Communications

Volume: 9, P: 1-11
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

The authors seek to understand the precise roles of microglia in the early human brain by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent stem cells (iMac).

Dong Shin Park
Tatsuya Kozaki
Florent Ginhoux
Research01 Nov 2023
Nature

Volume: 623, P: 397-405
Peripheral positioning of lysosomes supports melanoma aggressiveness

The function and position of organelles are pivotal for tumor cell dissemination. Here the authors use melanoma patient samples and animal models to show that peripheral localization of lysosomes promotes metastasis by favoring lysosome exocytosis and cell invasion.

Katerina Jerabkova-Roda
Marina Peralta
Jacky G. Goetz
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Margaux Sala
Nathalie Allain
Frédéric Saltel
Research23 Mar 2022
Oncogene

Volume: 41, P: 2571-2586
Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma

Sara Basbous
Lydia Dif
Violaine Moreau
ResearchOpen Access13 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-14
WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation

Bertrand Chauveau
Antoine Garric
Pierre Merville
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-14

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The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active

Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

Peripheral positioning of lysosomes supports melanoma aggressiveness

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma

WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation

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The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active

Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

Peripheral positioning of lysosomes supports melanoma aggressiveness

Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma

WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation

Search

Quick links