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Showing 1–4 of 4 results
Advanced filters: Author: Frédérique Dewitte Clear advanced filters

  • The Mediator complex subunit MED23 contributes to transcriptional activation by the phosphorylated transcription factor Elk-1, in response to Ras-MAPK signalling. Here, the authors determine a cryo-EM structure of human MED23 with the phosphorylated activation domain of Elk-1 providing insights into the Mediator subunit-transcription factor interface.

    • Didier Monté
    • Zoé Lens
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The fundamental processes of protein insertion and translocation at the outer membrane are mediated by Omp85 proteins. Here the authors report structures of the translocase FhaC, showing that the critical L6 loop adopts a conformation similar to that of related insertases; establishing a common structural basis for Omp85 function.

    • Timm Maier
    • Bernard Clantin
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.

    • Didier Monté
    • Bernard Clantin
    • Vincent Villeret
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7