Phosphatidylinositol 5-phosphate (PtdIns5P) is known to induce actin depolymerisation and cell migration; however, the mechanisms by which this occurs remain unclear. Viaud et al.show that PtdIns5P regulates actin dynamics and invasiveness by recruiting and activating the Rac-GTPase exchange factor Tiam1.
- Julien Viaud
- Frédéric Lagarrigue
- Frédérique Gaits-Iacovoni