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Showing 1–4 of 4 results
Advanced filters: Author: Françoise Debart Clear advanced filters

  • The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am demethylase activity, not through internal m6A demethylase activity.

    • Sébastien Relier
    • Julie Ripoll
    • Alexandre David
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • TheMononegaviralesinclude Ebola virus, Rabies, Measles virus and human Metapneumovirus (hMPV). Here, the authors have reported the high resolution crystal structure of a domain of the large protein of hMPV, providing insight into the mRNA modifying activities of this protein.

    • Guido C. Paesen
    • Axelle Collet
    • Jonathan M. Grimes
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Two different methylation states of the adenosine adjacent to the snRNA cap are found in the biogenesis process of snRNAs, Am and m6Am, whose levels are regulated by FTO and are related to alternative pre-mRNA splicing.

    • Jan Mauer
    • Miriam Sindelar
    • Samie R. Jaffrey
    Research
    Nature Chemical Biology
    Volume: 15, P: 340-347

  • Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preventing DCP2-mediated decapping.

    • Jan Mauer
    • Xiaobing Luo
    • Samie R. Jaffrey
    Research
    Nature
    Volume: 541, P: 371-375