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Showing 1–3 of 3 results
Advanced filters: Author: Frances Wallach Clear advanced filters

  • Tumour necrosis factor (TNF) was initially isolated as a factor that induced necrosis of cancer cells. However, it has become clear that TNF can also promote cancer. This Timeline examines the long history of TNF in cancer biology, asking whether it is a target, a therapeutic or both.

    • Frances Balkwill
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 361-371

  • Gaucher's disease is a lysosomal storage disease caused by mutations in the glucocerebrosidase gene. Now, Anthony Futerman and his colleagues report that the expression of proteins linked to a form of cell death called necroptosis is increased in Gaucher's disease and that blocking these proteins can improve disease in a mouse model.

    • Einat B Vitner
    • Ran Salomon
    • Anthony H Futerman
    Research
    Nature Medicine
    Volume: 20, P: 204-208