Nature Search

Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
CTLA-4–Ig regulates tryptophan catabolism in vivo

Ursula Grohmann
Ciriana Orabona
Paolo Puccetti
Research30 Sept 2002
Nature Immunology

Volume: 3, P: 1097-1101
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Molecular mechanism of thyroxine transport by monocarboxylate transporters

Structural biology approaches are used to show how thyroxine is transported by monocarboxylate transporters (MCT)8 and 10, and MCT8 inhibition by silychristin. These findings shed light on how a MCT8 patient-derived mutation alters its function.

Matteo Tassinari
Giorgia Tanzi
Francesca Coscia
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-11
The origin of modern North Africans as depicted by a massive survey of mitogenomes

Giulia Colombo
Elisabetta Moroni
Anna Olivieri
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level

Optogenetics is a powerful antiepileptic strategy in cases of drug resistance but light delivery to deep brain structure is hard to achieve. Here, authors develop a closed-loop chemo-optogenetic tool made of a luciferase, a sensor of intracellular pH, and an optogenetic actuator for silencing neuronal hyperactivity.

Assunta Merolla
Caterina Michetti
Fabio Benfenati
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-21
A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

Francesca Minnai
Filippo Biscarini
Francesca Colombo
ResearchOpen Access06 Feb 2024
Scientific Reports

Volume: 14, P: 1-14
Modulation of tryptophan catabolism by regulatory T cells

Francesca Fallarino
Ursula Grohmann
Paolo Puccetti
Research26 Oct 2003
Nature Immunology

Volume: 4, P: 1206-1212
Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies

Giulia Pintarelli
Antonella Galvan
Francesca Colombo
ResearchOpen Access01 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Local cooling and drying induced by Himalayan glaciers under global warming

High-elevation meteorological observations and reanalysis data indicate local cooling and drying near Himalayan glaciers due to enhanced katabatic winds in response to global warming.

Franco Salerno
Nicolas Guyennon
Francesca Pellicciotti
ResearchOpen Access04 Dec 2023
Nature Geoscience

Volume: 16, P: 1120-1127
An explainable model of host genetic interactions linked to COVID-19 severity

A multifaceted computational strategy identifies 16 genetic variants contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing dataset of a cohort of Italian patients.

Anthony Onoja
Nicola Picchiotti
Francesco Raimondi
ResearchOpen Access26 Oct 2022
Communications Biology

Volume: 5, P: 1-14
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Michael Seldin and colleagues report a genome-wide association study and meta-analyses for primary biliary cirrhosis. They identify three loci newly associated with susceptibility to this autoimmune liver disease.

Xiangdong Liu
Pietro Invernizzi
Michael F Seldin
Research18 Jul 2010
Nature Genetics

Volume: 42, P: 658-660
Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study

Phase 1 trial results reveal that intrathecal transplantation of human fetal neural precursor cells in patients with progressive multiple sclerosis is feasible, safe and tolerable.

Angela Genchi
Elena Brambilla
Gianvito Martino
ResearchOpen Access09 Jan 2023
Nature Medicine

Volume: 29, P: 75-85
Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response

Esposito et al. investigate the genetic basis of response to BNT162b2 mRNA COVID-19 vaccine in 1351 Italian subjects. They find variants in the human leukocyte antigen locus significantly associate with serum anti-SARS-CoV-2 antibody levels, after vaccination.

Martina Esposito
Francesca Minnai
Francesca Colombo
ResearchOpen Access04 Apr 2024
Communications Medicine

Volume: 4, P: 1-7
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

Serum Amyloid P is a humoral component with established roles in the response to bacterial infection and regulation of tissue remodeling. Here the authors provide evidence to a further crucial role of serum amyloid P in the context of fungal pathogen Aspergillus fumigatus.

Andrea Doni
Raffaella Parente
Alberto Mantovani
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-15
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Arterial hypertension and cystatin C during neonatal physiologic dehydration

Beatrice L. Crippa
Stefano Ghirardello
Gianluigi Ardissino
Research02 May 2021
Journal of Human Hypertension

Volume: 36, P: 554-560
Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy

Semiconducting polymer nanoparticles can act as light-sensitive interfaces with retinal neurons, and on microinjection in the eye, rescue vision in retinas affected by photoreceptor degeneration, offering a potential new treatment option for inherited retinal dystrophies and late-stage age-related macular degeneration.

José Fernando Maya-Vetencourt
Giovanni Manfredi
Fabio Benfenati
Research29 Jun 2020
Nature Nanotechnology

Volume: 15, P: 698-708
In vitro models of the crosstalk between multiple myeloma and stromal cells recapitulate the mild NF-κB activation observed in vivo

Federica Colombo
Virginia Guzzeloni
Alessandra Agresti
ResearchOpen Access06 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-18
Multicenter, randomised, open-label, non-comparative phase 2 trial on the efficacy and safety of the combination of bevacizumab and trabectedin with or without carboplatin in women with partially platinum-sensitive recurrent ovarian cancer

Nicoletta Colombo
Eleonora Zaccarelli
Maurizio D‘Incalci
ResearchOpen Access20 Sept 2019
British Journal of Cancer

Volume: 121, P: 744-750
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Haemochromatosis gene mutations in a clustered Italian population: evidence of high prevalence in people of Celtic ancestry

Gabriele Pozzato
Francesca Zorat
Antonio Amoroso
Research02 Jul 2001
European Journal of Human Genetics

Volume: 9, P: 445-451
Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons

This study shows that burst-firing-induced astrocyte signaling potentiates glutamatergic transmission onto dopamine neurons in mouse VTA.

Linda Maria Requie
Marta Gómez-Gonzalo
Giorgio Carmignoto
Research17 Nov 2022
Nature Neuroscience

Volume: 25, P: 1639-1650
Gut microbiota composition in colorectal cancer patients is genetically regulated

Francesca Colombo
Oscar Illescas
Manuela Gariboldi
ResearchOpen Access06 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Winter snow deficit was a harbinger of summer 2022 socio-hydrologic drought in the Po Basin, Italy

Low snow water equivalent in the Italian Alps during the 2021–2022 winter was a key cause of the subsequent summer drought in the Po River Basin, according to an assessment which combines satellite and ground-based data with water restriction records.

Francesco Avanzi
Francesca Munerol
Luca Ferraris
ResearchOpen Access03 Feb 2024
Communications Earth & Environment

Volume: 5, P: 1-12
Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Mattia Bellan
Giuseppe Patti
Pier Paolo Sainaghi
ResearchOpen Access26 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
A soft solid surface on Titan as revealed by the Huygens Surface Science Package

John C. Zarnecki
Mark R. Leese
John E. Geake
Research30 Nov 2005
Nature

Volume: 438, P: 792-795
Methane drizzle on Titan

In situ data from Saturn's moon Titan indicates an upper methane ice cloud and a lower, barely visible, liquid methane–nitrogen cloud, with a gap in between. The lower liquid cloud produces drizzle that reaches Titan's surface.

Tetsuya Tokano
Christopher P. McKay
Hasso B. Niemann
Research27 Jul 2006
Nature

Volume: 442, P: 432-435
Role of YAP/TAZ in mechanotransduction

Sirio Dupont
Leonardo Morsut
Stefano Piccolo
Research08 Jun 2011
Nature

Volume: 474, P: 179-183
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals.

Antonio Totaro
Martina Castellan
Stefano Piccolo
ResearchOpen Access17 May 2017
Nature Communications

Volume: 8, P: 1-13
DNA vaccination against the ovarian carcinoma-associated antigen folate receptor α (FRα) induces cytotoxic T lymphocyte and antibody responses in mice

Francesca Neglia
Anna Maria Orengo
Silvano Ferrini
Research01 Nov 1999
Cancer Gene Therapy

Volume: 6, P: 349-357
Investigating microRNAs as biomarkers in disorders of consciousness: a longitudinal multicenter study

Nicolò Musso
Dalida Bivona
Sergio Bagnato
ResearchOpen Access27 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
On-site monitoring of the performance of innovative treatments for marble conservation in architectural heritage

Francesca Gherardi
Davide Gulotta
Lucia Toniolo
ResearchOpen Access24 Jan 2017
Heritage Science

Volume: 5, P: 1-15
Long-term results of fertility-sparing treatment compared with standard radical surgery for early-stage epithelial ovarian cancer

Robert Fruscio
Lorenzo Ceppi
Cristina Maria Bonazzi
ResearchOpen Access18 Aug 2016
British Journal of Cancer

Volume: 115, P: 641-648
COVID-19 mortality in Italy varies by patient age, sex and pandemic wave

Francesca Minnai
Gianluca De Bellis
Francesca Colombo
ResearchOpen Access17 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Understanding communicative intentions in schizophrenia using an error analysis approach

Alberto Parola
Claudio Brasso
Francesca M. Bosco
ResearchOpen Access26 Feb 2021
npj Schizophrenia

Volume: 7, P: 1-9
One-carbon pathway and cognitive skills in children with Down syndrome

Francesca Antonaros
Silvia Lanfranchi
Maria Caracausi
ResearchOpen Access19 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients

Francesca Colombo
Giulia Pintarelli
Augusto Tommaso Caraceni
ResearchOpen Access17 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.

Martina Molgora
Eduardo Bonavita
Alberto Mantovani
Research25 Oct 2017
Nature

Volume: 551, P: 110-114
Plasma metabolome and cognitive skills in Down syndrome

Francesca Antonaros
Veronica Ghini
Maria Caracausi
ResearchOpen Access26 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Evaluation of genetic diversity among strains of the human gut commensal Bifidobacterium adolescentis

Sabrina Duranti
Christian Milani
Marco Ventura
ResearchOpen Access01 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

Stefania Mantovani
Sergio Daga
Alessandra Renieri
ResearchOpen Access24 Dec 2021
Genes & Immunity

Volume: 23, P: 51-56
A machine learning approach on whole blood immunomarkers to identify an inflammation-associated psychosis onset subgroup

Paolo Enrico
Giuseppe Delvecchio
Gianluca Rambaldelli
Research06 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1190-1200
Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

Chiara Battistini
Hilary A. Kenny
Ugo Cavallaro
ResearchOpen Access28 May 2024
Cell Death & Disease

Volume: 15, P: 1-13
Pathway-based analysis of primary biliary cirrhosis genome-wide association studies

S P Kar
M F Seldin
C I Amos
Research07 Feb 2013
Genes & Immunity

Volume: 14, P: 179-186
Two independent and primitive envelopes of the bilobate nucleus of comet 67P

The ‘onion-like’ stratification of the two lobes of the comet 67P/Churyumov–Gerasimenko reveals that its unusual shape is the result of a gentle collision merging two kilometre-sized objects in the early stages of the Solar System.

Matteo Massironi
Emanuele Simioni
Jean-Baptiste Vincent
Research28 Sept 2015
Nature

Volume: 526, P: 402-405

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