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Showing 1–3 of 3 results
Advanced filters: Author: Francesca N. Delling Clear advanced filters

  • Two mutations in the gene DCHS1 are shown to cause non-syndromic mitral valve prolapse (MVP), a common cardiac valve disease; understanding the role of DCHS1 in mitral valve development and MVP pathogenesis holds therapeutic potential.

    • Ronen Durst
    • Kimberly Sauls
    • Susan A. Slaugenhaupt
    Research
    Nature
    Volume: 525, P: 109-113

  • Mitral valve disease is a common cause of heart failure and death. In this Review from members of the Leducq Transatlantic Network, Levine and colleagues extensively summarize the molecular and cellular mechanisms underlying the dynamic changes that occur during progression of mitral valve disease, and indicate how improved understanding of the pathophysiology might lead to the discovery of novel therapeutic options.

    • Robert A. Levine
    • Albert A. Hagége
    • Magdi H. Yacoub
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 689-710

  • Christian Dina, Nabila Bouatia-Naji, Xavier Jeunemaitre and colleagues from the Leducq Transatlantic MITRAL Network report the results of a genome-wide association study of nonsyndromic mitral valve prolapse. They identify six susceptibility loci and provide functional evidence implicating LMCD1 and TNS1 as genes influencing mitral valve development.

    • Christian Dina
    • Nabila Bouatia-Naji
    • Xavier Jeunemaitre
    Research
    Nature Genetics
    Volume: 47, P: 1206-1211