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Showing 1–12 of 12 results
Advanced filters: Author: Francesca Odoardi Clear advanced filters

  • This work shows a distinct involvement of the meningeal layers in CNS autoimmunity. In animal models and in patients with multiple sclerosis, the leptomeninges were highly inflamed and showed structural changes, while the dura was only marginally affected.

    • Arianna Merlini
    • Michael Haberl
    • Francesca Odoardi
    Research
    Nature Neuroscience
    Volume: 25, P: 887-899

  • Work in experimental autoimmune models shows that the lung microbiome is linked to immune reactivity in the brain through a mechanism in which the balance of pulmonary microorganisms regulates the activation state of microglia.

    • Leon Hosang
    • Roger Cugota Canals
    • Francesca Odoardi
    Research
    Nature
    Volume: 603, P: 138-144

  • In a rat model of multiple sclerosis, β-synuclein-specific T cells induce inflammation and pathological changes in the grey matter of the central nervous system; these cells were also found in higher numbers in patients with multiple sclerosis, particularly those with a chronic progressive course.

    • Dmitri Lodygin
    • Moritz Hermann
    • Alexander Flügel
    Research
    Nature
    Volume: 566, P: 503-508

  • Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.

    • Stefan A. Berghoff
    • Lena Spieth
    • Gesine Saher
    Research
    Nature Neuroscience
    Volume: 24, P: 47-60

  • Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.

    • Stefan A. Berghoff
    • Nina Gerndt
    • Gesine Saher
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • By investigating trafficking of autoreactive T cells into the CSF during experimental autoimmune encephalitis, the authors find that T cells enter the CSF from the leptomeninges, and that commuting between the leptomeninges and the CSF is regulated by integrin adhesive forces triggered by T-cell activation and/or chemokines.

    • Christian Schläger
    • Henrike Körner
    • Alexander Flügel
    Research
    Nature
    Volume: 530, P: 349-353

  • The tissues of the central nervous system are shielded from the blood circulation by specialized vessels, impermeable to cells and most circulating macromolecules. Despite this, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attack. Here, intravital two-photon imaging is used to observe, in real-time, the interactive processes between effector T cells and cerebral structures leading to an experimental rat model of autoimmune encephalitis.

    • Ingo Bartholomäus
    • Naoto Kawakami
    • Alexander Flügel
    Research
    Nature
    Volume: 462, P: 94-98

  • A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

    • Francesca Odoardi
    • Christopher Sie
    • Alexander Flügel
    Research
    Nature
    Volume: 488, P: 675-679

  • The work of Dmitri Lodygin and his colleagues focuses on the important issue of when and where autoaggressive T cells are activated within their target organ to trigger autoimmune disease. Using intravital two-photon imaging and a new molecular sensor—a genetically encoded fluorescent sensor of nuclear factor of activated T cells (NFAT) combined with a fluorescently tagged version of nuclear histone protein H2B—the group was able to pinpoint key T cell activation events in experimental autoimmune encephalomyelitis, a model for multiple sclerosis.

    • Dmitri Lodygin
    • Francesca Odoardi
    • Alexander Flügel
    Research
    Nature Medicine
    Volume: 19, P: 784-790

  • A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin.

    • Francesca Odoardi
    • Winfried Neuhuber
    • Alexander Flügel
    Research Highlights
    Cell Research
    Volume: 24, P: 1021-1022