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Showing 1–12 of 12 results
Advanced filters: Author: Francesca Storici Clear advanced filters

  • Endogenous RNA transcripts are shown to mediate recombination with yeast chromosomal DNA; as the level of RNAs in the nucleus is quite high, these results may open up new understanding of the plasticity of repair and genome instability mechanisms.

    • Havva Keskin
    • Ying Shen
    • Francesca Storici
    Research
    Nature
    Volume: 515, P: 436-439

  • Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequence-specific manner, suggesting a direct role for RNA in modulating genome stability and evolution.

    • Youngkyu Jeon
    • Yilin Lu
    • Francesca Storici
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and nuclear DNA show preference for cytosine and guanosine preceded by deoxyadenosine.

    • Sathya Balachander
    • Alli L. Gombolay
    • Francesca Storici
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Ribonucleoside monophosphates (rNMPs) are often incorporated into genomic DNA. Misincorporated rNMPs are now shown to be repaired by mismatch repair and RNases H. If not repaired, they can serve as a template for DNA synthesis and can cause mutagenesis in Escherichia coli and yeast.

    • Ying Shen
    • Kyung Duk Koh
    • Francesca Storici
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 98-104

  • Although RNA is used to synthesize DNA by specialized enzymes such as reverse transcriptase and telomerase, it has never been shown to be used directly in DNA repair. Here Resnick and colleagues find that short RNA oligonucleotides which are complementary to the sequences at a DNA double-strand break can serve as a template for repair by the normal replicative DNA polymerases, suggesting that information contained in an RNA molecule could be transferred into the genome.

    • Francesca Storici
    • Katarzyna Bebenek
    • Michael A. Resnick
    Research
    Nature
    Volume: 447, P: 338-341

  • Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

    • Francesca Storici
    • Ailone E. Tichon
    News & Views
    Nature Cell Biology
    Volume: 19, P: 1382-1384