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DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumulation, and preserves accessibility of SOX2-bound enhancers.

Francesco Ferrari
Laura Arrigoni
Thomas Manke
ResearchOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1-13
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4

Long intergenic noncoding RNAs (lincRNAs) contribute to the regulation of gene expression. Pagani and colleagues identify hundreds of unique lincRNAs expressed in human lymphocytes and demonstrate a role for the lincRNA linc-MAF-4 in the differentiation of CD4⁺ T cells.

Valeria Ranzani
Grazisa Rossetti
Massimiliano Pagani
Research26 Jan 2015
Nature Immunology

Volume: 16, P: 318-325
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Amendments and Corrections07 Mar 2019
Nature Medicine

Volume: 25, P: 701
PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

Marzia Del Re
Riccardo Marconcini
Romano Danesi
ResearchOpen Access06 Mar 2018
British Journal of Cancer

Volume: 118, P: 820-824
Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco
Claudio Crema
Fabio Maria Triulzi
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-19
Author Correction: Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco
Claudio Crema
Fabio Maria Triulzi
Amendments and CorrectionsOpen Access18 Jan 2024
Scientific Reports

Volume: 14, P: 1
Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy

Federico Bruno
Alessia Catalucci
Carlo Masciocchi
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

CD98hc in macrophages attenuates the severity of colitis. This change in the macrophage development is associated with increased expression of apoptotic genes, suggesting that CD98hc maintains the gut homeostasis by ensuring the development of gut macrophages.

Philipp Wuggenig
Berna Kaya
Jan Hendrik Niess
ResearchOpen Access18 Mar 2020
Communications Biology

Volume: 3, P: 1-19
Germline APC Mutation on the β-Catenin Binding Site Is Associated with a Decreased Apoptotic Level in Colorectal Adenomas

Tiziana Venesio
Antonella Balsamo
Mauro Risio
Research01 Jan 2003
Modern Pathology

Volume: 16, P: 57-65
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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