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Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

Francesco Colucci
Edina Schweighoffer
James P. Di Santo
Research11 Feb 2002
Nature Immunology

Volume: 3, P: 288-294
Natural killer cell activation in mice and men: different triggers for similar weapons?

Francesco Colucci
James P. Di Santo
Paul J. Leibson
Reviews01 Sept 2002
Nature Immunology

Volume: 3, P: 807-813
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Saeedi Saravi and colleagues demonstrate an age-related increase in the gut microbial metabolite phenylacetic acid (PAA) in humans and mice, linked to Clostridium bacteria. In mice, they find that PAA triggers endothelial senescence, linking the microbiome to vascular aging.

Seyed Soheil Saeedi Saravi
Benoit Pugin
Jürg H. Beer
ResearchOpen Access12 May 2025
Nature Aging

Volume: 5, P: 1025-1045
Correction: Corrigendum: MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodeling

Jens Kieckbusch
Louise M. Gaynor
Francesco Colucci
Amendments and CorrectionsOpen Access20 Apr 2017
Nature Communications

Volume: 8, P: 1
Unexpected partnership between IL-15 and DAP10

Interleukin 15 (IL-15) is essential for natural killer (NK) cell development and function, and the adaptor DAP10 transmits important signals in NK cells. New work shows that IL-15 and DAP10 cross regulate each other.

Francesco Colucci
News & Views01 Dec 2007
Nature Immunology

Volume: 8, P: 1289-1291
Taming killer cells may halt diabetes progression

Preclinical studies in mice suggest that the natural killer cell receptor NKp46 may be a new molecular target for delaying the progression of type 1 diabetes by interfering with unexpected natural killer cell–mediated recognition of pancreatic beta cells.

Francesco Colucci
Corrado M Cilio
News & Views01 Feb 2010
Nature Immunology

Volume: 11, P: 111-112
Intellectual edge can be gained in translation

Francesco Colucci
Correspondence21 Mar 2007
Nature

Volume: 446, P: 372
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.

Oisín Huhn
Martin A. Ivarsson
Francesco Colucci
ResearchOpen Access20 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Decidualisation and placentation defects are a major cause of age-related reproductive decline

Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.

Laura Woods
Vicente Perez-Garcia
Myriam Hemberger
ResearchOpen Access05 Sept 2017
Nature Communications

Volume: 8, P: 1-15
Trans - Perineal laser ablation of the prostate in high surgical risk patients affected by severe lower urinary tract symptoms related to benign prostatic obstruction

Paolo Destefanis
Mattia Sibona
Paolo Gontero
Research18 Oct 2023
Prostate Cancer and Prostatic Diseases

Volume: 27, P: 693-699
Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Studying the uterine lymphocyte pool is difficult due to its dynamic nature induced by various pregnancy-related factors. Here the authors provide, using transcriptome data from sorted mouse group 1 innate lymphoid cells (ILC), a molecular atlas of these cells, which implicates tissue-resident natural killer cells as a hub for uterine immune crosstalk.

Iva Filipovic
Laura Chiossone
Francesco Colucci
ResearchOpen Access29 Oct 2018
Nature Communications

Volume: 9, P: 1-13
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

Alexandra Barry
Michelle T. McNulty
Matthew G. Sampson
ResearchOpen Access29 Apr 2023
Nature Communications

Volume: 14, P: 1-13
MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling

NK cells are involved in remodelling of the uterine vasculature during pregnancy and the extent of this process is influenced by the combination of maternal NK cell receptors and MHC-I of the fetus. Here, the authors provide further insights into how the presence of MHC-I from each parent differentially affects NK cell function.

Jens Kieckbusch
Louise M. Gaynor
Francesco Colucci
ResearchOpen Access28 Feb 2014
Nature Communications

Volume: 5, P: 1-13
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases

Simona Zompi
Jessica A Hamerman
Francesco Colucci
Research11 May 2003
Nature Immunology

Volume: 4, P: 565-572
Enrichment of CD56^dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

The role of NK cells in tumour lymphatics is poorly understood. Here, the authors show that the tumour cell-infiltrated lymph nodes of melanoma patients have an altered cytokine milieu and contain an expanded population of NK cells with high tumour-cytotoxic activity.

Talib Hassan Ali
Simona Pisanti
Ennio Carbone
Research04 Dec 2014
Nature Communications

Volume: 5, P: 1-9
What does it take to make a natural killer?

Francesco Colucci
Michael A. Caligiuri
James P. Di Santo
Reviews01 May 2003
Nature Reviews Immunology

Volume: 3, P: 413-425
A next-generation GMMA-based vaccine candidate to fight shigellosis

Omar Rossi
Francesco Citiulo
Francesca Micoli
ResearchOpen Access05 Sept 2023
npj Vaccines

Volume: 8, P: 1-10
The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis

Costanzo Padovano
Salvatore Daniele Bianco
Vincenzo Giambra
ResearchOpen Access01 Dec 2023
Scientific Reports

Volume: 13, P: 1-12
Biology and pathology of the uterine microenvironment and its natural killer cells

Fuyan Wang
Anita Ellen Qualls
Francesco Colucci
ReviewsOpen Access23 Aug 2021
Cellular & Molecular Immunology

Volume: 18, P: 2101-2113
Maternal natural killer cells at the intersection between reproduction and mucosal immunity

Evgeniya V. Shmeleva
Francesco Colucci
ReviewsOpen Access26 Apr 2021
Mucosal Immunology

Volume: 14, P: 991-1005
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria

Stephen Tukwasibwe
Annettee Nakimuli
Francesco Colucci
Reviews15 Jun 2020
Cellular & Molecular Immunology

Volume: 17, P: 799-806

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