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Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7

The authors explore sequence-encoded molecular grammar underlying the liquid liquid phase-separation of the human RNA polymerase II C-terminal domain and demonstrate that phase-separation appears to accelerate on phosphorylation by CDK7.

Katerina Linhartova
Francesco Luca Falginella
Richard Stefl
ResearchOpen Access24 Oct 2024
Nature Communications

Volume: 15, P: 1-17

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Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7

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