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Showing 1–3 of 3 results
Advanced filters: Author: Franci Merzel Clear advanced filters

  • The structure and function of membrane proteins depend on lipid interactions. Cryo-EM analysis of the actinoporin Fav pore reveals octameric structure binding 112 lipids and clusters of cholesterols. Molecular simulations highlight complex protein-lipid interactions crucial for structure.

    • Gašper Šolinc
    • Marija Srnko
    • Gregor Anderluh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Mur ligase D (MurD) is a promising antibacterial target, but its dynamics remain underexplored. Here, the authors use 15N nuclear magnetic resonance to probe apo and bound states of MurD in solution, showing that dynamic events on a time scale of picoseconds to milliseconds have to be considered in the design of structurally novel Mur inhibitors.

    • Iza Ogris
    • Barbara Zupančič
    • Simona Golič Grdadolnik
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-15

  • Capsid proteins (CPs) of various icosahedral and rod-shaped viruses exhibit structural diversity and tunability as well as application in smart hybrid nanoparticles, however, the potential of CPs of filamentous plant viruses remains underexplored. Here, the authors exploit the structure-based design of CP from potato virus Y to tune the shape, size, RNA encapsidation ability, symmetry, stability, and surface functionalization of nanoparticles.

    • Luka Kavčič
    • Andreja Kežar
    • Marjetka Podobnik
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-19