Nature Search

Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Juan Jose Rodriguez-Sevilla
Irene Ganan-Gomez
Simona Colla
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Mapping genotypes to chromatin accessibility profiles in single cells

The JAK2^V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with myeloproliferative neoplasms.

Franco Izzo
Robert M. Myers
Dan A. Landau
Research08 May 2024
Nature

Volume: 629, P: 1149-1157
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Multi-modality single-cell sequencing determines genotype, transcriptome and methylome information in cells from individuals with DNMT3A R882 mutated clonal hematopoiesis, allowing for the comparison of mutant and wild-type cells from the same individuals.

Anna S. Nam
Neville Dusaj
Dan A. Landau
Research22 Sept 2022
Nature Genetics

Volume: 54, P: 1514-1526
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

Multimodal DNA methylation and transcriptome profiling of single glioma cells links tumor cell transcriptional states to epigenetics via interaction with PRC2 and shows that these states are heritable and important for tumor plasticity.

Ronan Chaligne
Federico Gaiti
Dan A. Landau
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1469-1479
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation

Mosquito-borne viruses are serious global public health threats associated with severe atypical cardiovascular manifestations. Here, the authors dissect how chikungunya virus directly infects cardiac tissue leading to heart disease and define key host pathways involved in viral cardiac persistence and tissue damage.

Maria G. Noval
Sophie N. Spector
Kenneth A. Stapleford
ResearchOpen Access03 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Profiling of over 38,000 CD34⁺ cells from patients with CALR-mutated myeloproliferative neoplasms, using the ‘Genotyping of Transcriptomes’ procedure, reveals that the transcriptional output of these mutations depends upon native cell identity.

Anna S. Nam
Kyu-Tae Kim
Dan A. Landau
Research03 Jul 2019
Nature

Volume: 571, P: 355-360
DNA methylation disruption reshapes the hematopoietic differentiation landscape

Single-cell analysis of mouse hematopoietic stem cells shows that mutations in DNA methylation genes change the frequencies of erythroid versus myelomonocytic progenitors, owing to differential CpG enrichment in transcription factor binding motifs.

Franco Izzo
Stanley C. Lee
Dan A. Landau
Research23 Mar 2020
Nature Genetics

Volume: 52, P: 378-387
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access01 Jul 2021
Nature Physics

Volume: 17, P: 819-825
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
A kilonova as the electromagnetic counterpart to a gravitational-wave source

Observations and modelling of an optical transient counterpart to a gravitational-wave event and γ-ray burst reveal that neutron-star mergers produce gravitational waves and radioactively powered kilonovae, and are a source of heavy elements.

S. J. Smartt
T.-W. Chen
O. Yaron
Research16 Oct 2017
Nature

Volume: 551, P: 75-79
Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Santiago Madera
Franco Izzo
Rosalía I. Cordo Russo
ResearchOpen Access09 May 2022
Cell Death & Disease

Volume: 13, P: 1-14
Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth

María F. Chervo
Rosalía I. Cordo Russo
Patricia V. Elizalde
Research25 Aug 2020
Oncogene

Volume: 39, P: 6245-6262
Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

Alesia Walker
Barbara Pfitzner
Philippe Schmitt-Kopplin
Research06 Jun 2014
The ISME Journal

Volume: 8, P: 2380-2396
Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

G. Aad
B. Abbott
L. Zwalinski
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E5
Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Santiago Madera
Franco Izzo
Rosalía I. Cordo Russo
Amendments and CorrectionsOpen Access15 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-3

Search

Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Mapping genotypes to chromatin accessibility profiles in single cells

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Observation of quantum entanglement with top quarks at the ATLAS detector

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

A kilonova as the electromagnetic counterpart to a gravitational-wave source

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth

Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

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