Nature Search

The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity

Marc P. Hübner
Dennis de Coninck
Indulekha Karunakaran
ResearchOpen Access18 Sept 2025
Cellular & Molecular Immunology

P: 1-13
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Here the authors conduct a multi-ancestry meta-analysis of telomere length, used diverse approaches to identify genes underlying association signals, and experimentally validated POP5 and KBTBD6 as regulators of telomere length in human cells.

Rebecca Keener
Surya B. Chhetri
Alexis Battle
ResearchOpen Access24 May 2024
Nature Communications

Volume: 15, P: 1-21
Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts

Jip W. T. M. de Kok
Frank van Rosmalen
Bas C. T. van Bussel
ResearchOpen Access10 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
PBRM1 directs PBAF to pericentromeres and protects centromere integrity

Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer, helps to maintain the integrity of centromeres.

Karen A. Lane
Alison Harrod
Jessica A. Downs
ResearchOpen Access26 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice.

Ravikanth Nanduri
Takashi Furusawa
Michael Bustin
ResearchOpen Access26 Nov 2022
Nature Communications

Volume: 13, P: 1-15
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

Roy et al. describe a generalized method for computationally designing miniproteins selective for a single integrin heterodimer and conformational state. The designed αvβ6 inhibitor remains monomeric and maintains biological activity following aerosolization and shows excellent efficacy in bleomycin induced lung fibrosis.

Anindya Roy
Lei Shi
David Baker
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-18
ABCB5 is a limbal stem cell gene required for corneal development and repair

The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.

Bruce R. Ksander
Paraskevi E. Kolovou
Natasha Y. Frank
Research02 Jul 2014
Nature

Volume: 511, P: 353-357
Transcriptional regulator PRDM12 is essential for human pain perception

Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.

Ya-Chun Chen
Michaela Auer-Grumbach
Jan Senderek
Research25 May 2015
Nature Genetics

Volume: 47, P: 803-808
Breast cancer screening in women with chronic kidney disease: the unrecognized effects of metastatic soft-tissue calcification

Patients with chronic kidney disease are known to develop metastatic soft-tissue calcification in tissues including the breast. Such calcifications in women could pose a problem for interpretation of mammograms. Authors from Staten Island University Hospital, NY review the available data on the prevalence and types of breast calcifications in women with chronic kidney disease, and discuss the utility of mammography in this setting.

Mario R Castellanos
Kavitha Paramanathan
Morton Kleiner
Reviews15 Apr 2008
Nature Clinical Practice Nephrology

Volume: 4, P: 337-341
Iron metabolism in a mouse model of hepatocellular carcinoma

Dilay Yilmaz
Umesh Tharehalli
Vujić Spasić Maja
ResearchOpen Access16 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
The structural basis of modified nucleosome recognition by 53BP1

A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety), and provides insight into the highly specified recognition and recruitment of 53BP1 to modified chromatin.

Marcus D. Wilson
Samir Benlekbir
Daniel Durocher
Research27 Jul 2016
Nature

Volume: 536, P: 100-103
Lung cancer in never smokers (LCINS): development of a UK national research strategy

Sam Khan
Nathaniel Hatton
Matthew Hatton
ReviewsOpen Access20 Jul 2023
BJC Reports

Volume: 1, P: 1-9
Miscibility in Blends of Stereoregular Poly(methyl methacrylate)s with Chlorinated Polyethylenes and Chlorinated Poly(vinyl chloride)s

Hiroyoshi Ueda
Frank E Karasz
Research01 Jul 1994
Polymer Journal

Volume: 26, P: 771-778
Joint contribution of polygenic scores for depression and attention-deficit/hyperactivity disorder to youth suicidal ideation and attempt

Massimiliano Orri
Genevieve Morneau-Vaillancourt
Michel Boivin
Research04 Apr 2025
Molecular Psychiatry

Volume: 30, P: 4085-4093
Achievability of 3D planned bimaxillary osteotomies: maxilla-first versus mandible-first surgery

Jeroen Liebregts
Frank Baan
Tong Xi
ResearchOpen Access24 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
One-year postoperative skeletal stability of 3D planned bimaxillary osteotomies: maxilla-first versus mandible-first surgery

Jeroen Liebregts
Frank Baan
Tong Xi
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
One-year clinical results of restorations using a novel self-adhesive resin-based bulk-fill restorative

Andreas Rathke
Frank Pfefferkorn
Rainer Seemann
ResearchOpen Access10 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF

Maha M. Bakhuraysah
Paschalis Theotokis
Steven Petratos
ResearchOpen Access03 Feb 2021
Scientific Reports

Volume: 11, P: 1-16
Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology

Marie Rieux
Melanie Alpaugh
Francesca Cicchetti
Research08 Jun 2020
Molecular Psychiatry

Volume: 26, P: 5441-5463
Climatic suitability, isolation by distance and river resistance explain genetic variation in a Brazilian whiptail lizard

Eliana Faria Oliveira
Pablo Ariel Martinez
Gabriel Correa Costa
Research14 Dec 2017
Heredity

Volume: 120, P: 251-265

Search

The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts

PBRM1 directs PBAF to pericentromeres and protects centromere integrity

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

ABCB5 is a limbal stem cell gene required for corneal development and repair

Transcriptional regulator PRDM12 is essential for human pain perception

Breast cancer screening in women with chronic kidney disease: the unrecognized effects of metastatic soft-tissue calcification

Iron metabolism in a mouse model of hepatocellular carcinoma

The structural basis of modified nucleosome recognition by 53BP1

Lung cancer in never smokers (LCINS): development of a UK national research strategy

Miscibility in Blends of Stereoregular Poly(methyl methacrylate)s with Chlorinated Polyethylenes and Chlorinated Poly(vinyl chloride)s

Joint contribution of polygenic scores for depression and attention-deficit/hyperactivity disorder to youth suicidal ideation and attempt

Achievability of 3D planned bimaxillary osteotomies: maxilla-first versus mandible-first surgery

One-year postoperative skeletal stability of 3D planned bimaxillary osteotomies: maxilla-first versus mandible-first surgery

One-year clinical results of restorations using a novel self-adhesive resin-based bulk-fill restorative

B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF

Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology

Climatic suitability, isolation by distance and river resistance explain genetic variation in a Brazilian whiptail lizard

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