As men age, physiological changes take place that can result in late-onset hypogonadism. A number of comorbid conditions are thought to be implicated in the endocrinological changes associated with aging, but their role is yet to be determined. In this Review the authors discuss the pathophysiological mechanisms behind late-onset hypogonadism and age-related endocrinological changes in men.
- Ahmed Mahmoud
- Frank H Comhaire
