Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Frank J Poelwijk Clear advanced filters

  • The authors present a method for determining 3D protein structures using high-throughput mutation experiments. Pairs of residues with the largest positive epistasis are sufficient to determine the 3D fold.

    • Nathan J. Rollins
    • Kelly P. Brock
    • Debora S. Marks
    Research
    Nature Genetics
    Volume: 51, P: 1170-1176

  • Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of high-order epistatic interactions.

    • Frank J. Poelwijk
    • Michael Socolich
    • Rama Ranganathan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired properties and functions.

    • John B. Ingraham
    • Max Baranov
    • Gevorg Grigoryan
    ResearchOpen Access
    Nature
    Volume: 623, P: 1070-1078

  • The global effects of epistasis on protein and RNA function are revealed by an unsupervised model of amino acid co-conservation in evolutionary sequence variation.

    • Thomas A Hopf
    • John B Ingraham
    • Debora S Marks
    Research
    Nature Biotechnology
    Volume: 35, P: 128-135

  • A high-throughput mutagenesis study in a PDZ domain shows that biochemical function and adaptation primarily originate from a collectively evolving amino acid network within the structure termed a protein sector.

    • Richard N. McLaughlin Jr
    • Frank J. Poelwijk
    • Rama Ranganathan
    Research
    Nature
    Volume: 491, P: 138-142