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Showing 1–5 of 5 results
Advanced filters: Author: Frans Schutgens Clear advanced filters

  • Clevers et al. describe the establishment of tubuloid cultures from tissue and urine, as well as the generation and characterization of tubuloid cell–derived 3D tubular structures in a perfused microfluidic multi-chip platform.

    • Linda Gijzen
    • Fjodor A. Yousef Yengej
    • Hans Clevers
    Protocols
    Nature Protocols
    Volume: 16, P: 2023-2050

  • Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.

    • Camilla Calandrini
    • Frans Schutgens
    • Jarno Drost
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Human adult stem or progenitor cell organoid cultures have been established for multiple organs and have proved valuable in the basic study of pathophysiology as well as in clinical applications. Such an organoid culture system has not yet, however, been developed for the kidney. Here the authors describe the development and application of the available adult stem or progenitor cell organoid cultures, the challenges and feasibility of developing such a system for the kidney, and the potential kidney-specific applications of organoids.

    • Maarten B. Rookmaaker
    • Frans Schutgens
    • Hans Clevers
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 546-554