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Showing 1–10 of 10 results
Advanced filters: Author: Frederic Mentink-Vigier Clear advanced filters

  • Echinocandins inhibit the biosynthesis of β−1,3-glucan, an essential component of the fungal cell wall, but their efficacy against the pathogen Aspergillus fumigatus is limited. Here, Dickwella Widanage et al. show that A. fumigatus responds to echinocandin treatment by remodelling various cell wall polymers, thus maintaining cell wall integrity and modulating the permeability and circulation of the drug in the cell wall.

    • Malitha C. Dickwella Widanage
    • Isha Gautam
    • Tuo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Chlamydomonas reinhardtii produces a glycoprotein-rich cell wall. Using nuclear magnetic resonance and mass spectrometry approaches, this study reveals unprecedented details on its protein and carbohydrate content, and provide an atomic-level architecture model.

    • Alexandre Poulhazan
    • Alexandre A. Arnold
    • Isabelle Marcotte
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The plant biomass is a composite formed by a variety of polysaccharides and an aromatic polymer named lignin. Here, the authors use solid-state NMR spectroscopy to unveil the carbohydrate-aromatic interface that leads to the variable architecture of lignocellulose biomaterials.

    • Alex Kirui
    • Wancheng Zhao
    • Tuo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • γ-Al2O3 is widely used in catalytic processes, but understanding its detailed structure remains a challenge. The authors, using two-dimensional solid-state NMR spectroscopy at a high magnetic field, characterize the spatial proximity and connectivity between oxygen species from the bulk to the surface.

    • Qiang Wang
    • Wenzheng Li
    • Feng Deng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • The interactions of lignin with polysaccharides in plant secondary cell walls are not well understood. Here the authors employ solid-state NMR measurements to analyse intact stems of maize, Arabidopsis, switchgrass and rice and observe that lignin self-aggregates and forms highly hydrophobic microdomains that make extensive surface contacts to xylan.

    • Xue Kang
    • Alex Kirui
    • Tuo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Lustrous flexible thin films of semiconducting cyclic polyacetylene (c-PA) have been synthesized and characterized. Rapid and efficient tungsten-catalysed acetylene polymerization conditions produce temporarily soluble c-PA, enabling the in situ derivatization of this typically insoluble polymer. Compelling evidence for the cyclic topology—and its influence on the physical properties of the polymer—are presented.

    • Zhihui Miao
    • Stella A. Gonsales
    • Adam S. Veige
    Research
    Nature Chemistry
    Volume: 13, P: 792-799

  • Aspergillus fumigatus is a pathogenic fungus. Here the authors perform solid-state NMR measurements with intact Aspergillus cells, which provides insights into cell wall composition and dynamics and propose a structural model for fungal cell walls.

    • Xue Kang
    • Alex Kirui
    • Tuo Wang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Amyloidogenic aggregation of β-amyloid (Aβ) peptides disrupts cellular membranes and is a viable cytotoxicity mechanism in Alzheimer’s disease, but studying the underlying molecular behavior is challenging due to peptide heterogeneity and low abundance. Here, the authors use solid-state nuclear magnetic resonance spectroscopy to show that, compared to the less pathogenic Aβ1-40 peptide, Aβ1-42 forms smaller oligomers prior to fibrillation and exhibits more pronounced residue-specific contacts with phospholipid headgroups.

    • Maurine K. Kengwerere
    • June M. Kenyaga
    • Wei Qiang
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-10