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Showing 1–11 of 11 results
Advanced filters: Author: Frederic Poitevin Clear advanced filters

  • The authors devise an algorithm to reconstruct proteins from X-ray single particle data, unlocking the ability to process datasets online, in a single pass. The technique matches or outperforms existing methods in simulation and on experimental data.

    • Jay Shenoy
    • Axel Levy
    • Gordon Wetzstein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Using resonance Raman spectroscopy and serial femtosecond X-ray crystallography, the authors show the heme a3 iron and CuB in the resting oxidized form of Cytochrome c Oxidase are coordinated by a hydroxide ion and a water molecule, respectively.

    • Izumi Ishigami
    • Raymond G. Sierra
    • Denis L. Rousseau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Small-molecule serial femtosecond X-ray crystallography (smSFX) characterizes microcrystals by indexing sparse serial XFEL diffraction frames, with little sample preparation, without beam damage, and at room temperature and pressure.

    • Elyse A. Schriber
    • Daniel W. Paley
    • J. Nathan Hohman
    ResearchOpen Access
    Nature
    Volume: 601, P: 360-365

  • The first X-ray crystal structure of the mouse serotonin 5-HT3 receptor, a pentameric ligand-gated ion channel, is similar to those of other Cys-loop receptors — though here electron density for part of the cytoplasmic domain, which is important for trafficking, synaptic localization, and modulation by cytoplasmic proteins, but not visible in previous structures, is also described.

    • Ghérici Hassaine
    • Cédric Deluz
    • Hugues Nury
    Research
    Nature
    Volume: 512, P: 276-281

  • Although the photocycle of the photosensory core module of the Stigmatella aurantiaca bacteriophytochrome 2 (SaBphP2) has been extensively studied, its early dynamics have not been fully resolved. Here, the authors use time-resolved serial femtosecond crystallography to probe the associated picosecond events and report on the relative population of Z and E isomers after light activation.

    • Tek Narsingh Malla
    • Luis Aldama
    • Marius Schmidt
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-10

  • Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic signaling in response to neurotransmitter binding, but the conformational changes induced by neurotransmitter binding are unknown. The crystal structures of mutated GLIC, a bacterial pLGIC homolog, reveal a novel, locally closed channel conformation that provides insight into pLGIC allosteric transitions.

    • Marie S Prevost
    • Ludovic Sauguet
    • Pierre-Jean Corringer
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 642-649

  • Ayan et al. report two structures of the protein streptavidin - one at ambient temperature determined using serial femtosecond crystallography and a second one determined at cryogenic temperature. These results provide insights into the structural dynamics of apo streptavidin and reveal a cooperative allostery between monomers for binding to biotin, and the findings are supported by GNM analysis.

    • Esra Ayan
    • Busra Yuksel
    • Hasan DeMirci
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13