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Showing 1–9 of 9 results
Advanced filters: Author: Frederick J Sheedy Clear advanced filters

  • Toll-like receptor (TLR) signaling activates the transcription factor NF-κB and production of proinflammatory cytokines. O'Neill and colleagues show that TLR signaling induces the microRNA miR-21 to dampen PDCD4 expression, which leads to less NF-κB activity and more IL-10 production.

    • Frederick J Sheedy
    • Eva Palsson-McDermott
    • Luke A J O'Neill
    Research
    Nature Immunology
    Volume: 11, P: 141-147

  • von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses.

    • Clive Drakeford
    • Sonia Aguila
    • James S. O’Donnell
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Signaling via the interleukin 1 (IL-1) family, particularly by IL-1β, has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1α to promote vascular inflammation identify a key role for this less-well-studied cytokine.

    • Frederick J Sheedy
    • Kathryn J Moore
    News & Views
    Nature Immunology
    Volume: 14, P: 1030-1032

  • Obesity is marked by a state of low-grade inflammation, including the accumulation of macrophages in the adipose tissue, which results in insulin resistance. Kathryn Moore and her colleagues now show that the neuronal guidance molecule, netrin-1, is upregulated in fat cells during obesity and leads to the retention of macrophages in this tissue. They also show that its genetic deletion in mice prevents the development of insulin resistance by a high-fat diet.

    • Bhama Ramkhelawon
    • Elizabeth J Hennessy
    • Kathryn J Moore
    Research
    Nature Medicine
    Volume: 20, P: 377-384

  • Particulate crystals can activate the NLRP3 inflammasome. Moore and colleagues show that the scavenger protein CD36 contributes to sterile inflammation via uptake of soluble cholesterol and amyloid peptides that nucleate into intracellular crystals.

    • Frederick J Sheedy
    • Alena Grebe
    • Kathryn J Moore
    Research
    Nature Immunology
    Volume: 14, P: 812-820

  • In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression.

    • Kathryn J. Moore
    • Frederick J. Sheedy
    • Edward A. Fisher
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 709-721

  • Toll-like receptors (TLRs) are central to the induction of pro-inflammatory responses, but their signalling pathways must be tightly regulated. As discussed in this article, an emerging level of fine-tuning is mediated by microRNAs, several of which are induced by TLR signalling.

    • Luke A. O'Neill
    • Frederick J. Sheedy
    • Claire E. McCoy
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 163-175