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Showing 1–50 of 241 results

Advanced filters: Author: Frederick Lo Clear advanced filters

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

Francesco Colucci
Edina Schweighoffer
James P. Di Santo
Research11 Feb 2002
Nature Immunology

Volume: 3, P: 288-294
Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

Analyses of whole-genome sequencing data from UK Biobank and All of Us identify rare variant burden signals associated with metabolic health, including effects of protein-truncating variants in IRS2 on type 2 diabetes and chronic kidney disease risk.

Yajie Zhao
Sam Lockhart
John R. B. Perry
ResearchOpen Access10 Oct 2025
Nature Genetics

Volume: 57, P: 2436-2444
A Further Study Of Catecholamine O-Methylation in Schizophrenia

ARTHUR F. WAGNER
VINCENT J. CIRILLO
NORMAN G. BRINK
Research06 Aug 1966
Nature

Volume: 211, P: 604-605
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Lo and behold, a role for lomustine in acute myeloid leukemia?

Adding lomustine to the standard combination of idarubicin and cytarabine for the treatment of old patients with acute myeloid leukemia improves complete response rates and overall survival. These findings emphasize the importance of dose intensity and raise the question of a unique role for nitrosoureas in the treatment of this disease.

Frederick R. Appelbaum
News & Views28 Oct 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 619-621
A candidate mouse model for Prader–Willi syndrome which shows an absence of Snrpn expression

Bruce M. Cattanach
Jacqueline A. Barr
Janet Jones
Research01 Dec 1992
Nature Genetics

Volume: 2, P: 270-274
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

Singer and colleagues show that let-7 microRNAs target Zbtb16 mRNA, which encodes the transcription factor PLZF, to modulate PLZF expression during the terminal differentiation of NKT cells into effector subsets.

Leonid A Pobezinsky
Ruth Etzensperger
Alfred Singer
Research06 Apr 2015
Nature Immunology

Volume: 16, P: 517-524
Gα13 restricts nutrient driven proliferation in mucosal germinal centers

Muppidi and colleagues show that loss of Gα13 drives B cell lymphomas preferentially in the mesenteric lymph nodes. They find that Gα13 is required to counteract mTORC1 and Myc signaling that is driven by the availability of dietary glutamine.

Hang T. Nguyen
Moyi Li
Jagan R. Muppidi
ResearchOpen Access18 Jul 2024
Nature Immunology

Volume: 25, P: 1718-1730
Endothelial apoptosis in Braf-deficient mice

Leszek Wojnowski
Anne M. Zimmer
Andreas Zimmer
Research01 Jul 1997
Nature Genetics

Volume: 16, P: 293-297
Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

Histone post-translational modifications such as the trimethylation of histone H3 at lysine 27 (H3K27Me3), affect DNA accessibility and transcription. Here, the authors show that Jmjd3 and Utx, two H3K27Me3 demethylases, are important for regulating the expression of genes involved in terminal thymocyte differentiation.

Sugata Manna
Jong Kyong Kim
Rémy Bosselut
ResearchOpen Access02 Sept 2015
Nature Communications

Volume: 6, P: 1-12
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Jiacheng He
Xiaolei Chai
Weiqiang Lu
Research04 Feb 2025
Nature Immunology

Volume: 26, P: 391-403
Conformational switching in an aspartic proteinase

Angela Y. Lee
Sergei V. Gulnik
John W. Erickson
Research01 Oct 1998
Nature Structural Biology

Volume: 5, P: 866-871
Mediation of mouse natural cytotoxic activity by tumour necrosis factor

John R. Ortaldo
Llewellyn H. Mason
Ronald B. Herberman
Research12 Jun 1986
Nature

Volume: 321, P: 700-702
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Starqardt macular dystrophy

Rando Allikmets
Nanda Singh
James R. Lupski
Research01 Mar 1997
Nature Genetics

Volume: 15, P: 236-246
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

Walter Kolch
Gisela Heidecker
Ulf R. Rapp
Research31 Jan 1991
Nature

Volume: 349, P: 426-428
Purified cardiac cell membranes with high (Na⁺ + K⁺) ATPase activity contain significant NADH-vanadate reductase activity

Erland Erdmann
Wolfgang Krawietz
Frederick L. Crane
Research15 Nov 1979
Nature

Volume: 282, P: 335-336
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

New antimalarials are urgently needed. Here, the authors identify Open Source Malaria compound, OSMS-106, as a reaction hijacking inhibitor of the malaria parasite protein synthesis machinery, with potential use for treatment and prophylaxis.

Stanley C. Xie
Yinuo Wang
Leann Tilley
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-18
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

Xuguang Tai
Michelle Cowan
Alfred Singer
Research09 Jan 2005
Nature Immunology

Volume: 6, P: 152-162
Nucleolar and Cytoplasmic Ribonucleic Acid Inhibition by Excess Thymidine

FREDERICK H. KASTEN
FREDY F. STRASSER
MARIAN TURNER
Research10 Jul 1965
Nature

Volume: 207, P: 161-164
Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia

Jacqueline T. Hecht
Laura D. Nelson
Jack Lawler
Research01 Jul 1995
Nature Genetics

Volume: 10, P: 325-329
Identification of an interferon in murine placentas

Arnold K. Fowler
Carl D. Reed
David J. Giron
Research17 Jul 1980
Nature

Volume: 286, P: 266-267
Unusual filterable oncogenic agent isolated from horizontally transmitted Syrian hamster lymphomas

Joseph H. Coggin Jr
John E. Oakes
Ray Gilden
Research26 Mar 1981
Nature

Volume: 290, P: 336-338
Chronic immune stimulation is required for Moloney leukaemia virus-induced lymphomas

John C. Lee
James N. Ihle
Research29 Jan 1981
Nature

Volume: 289, P: 407-409
IKKα deficiency disrupts the development of marginal zone and follicular B cells

Mumtaz Y. Balkhi
Jami Willette-Brown
Yinling Hu
Research08 May 2018
Genes & Immunity

Volume: 20, P: 224-233
Selective growth of natural cytotoxic but not natural killer effector cells in interleukin-3

Julie Y. Djeu
Emanuela Lanza
Andrew J. Hapel
Research22 Dec 1983
Nature

Volume: 306, P: 788-791
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation

The importance of STAT5 tyrosine phosphorylation on T cells has not been investigated in vivo. Here the authors generate STAT5A and STAT5B tyrosine mutant knockin mice and show that Stat5a/b tyrosine is required for maximal IL-2 signaling and CD8 + T cell proliferation.

Jian-Xin Lin
Meili Ge
Warren J. Leonard
ResearchOpen Access27 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Control of epithelial tissue organization by mRNA localization

Subcellular mRNA localization is prevalent but with poorly understood physiological roles. Here, the authors show that Net1 mRNA targeting to the basement membrane controls epithelial tissue organization and keratinocyte-stromal connections.

Devon E. Mason
Thomas D. Madsen
Stavroula Mili
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-14
A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop

Zuoxiang Xiao
Gongping Shi
Yinling Hu
ResearchOpen Access21 Oct 2022
Cell Death & Disease

Volume: 13, P: 1-14
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Dionisio Martin-Zanca
Stephen H. Hughes
Mariano Barbacid
Research27 Feb 1986
Nature

Volume: 319, P: 743-748
HIV infection induces changes in CD4⁺ T-cell phenotype and depletions within the CD4⁺ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

Mark Connors
Joseph A. Kovacs
H. Clifford Lane
Research01 May 1997
Nature Medicine

Volume: 3, P: 533-540
The α Rays of Radium

FREDERICK SODDY
Research11 Feb 1904
Nature

Volume: 69, P: 343
Serum Enzyme Changes during Sleep Deprivation

DAVID J. KUPFER
HERBERT Y. MELTZER
FREDERICK SNYDER
Research21 Nov 1970
Nature

Volume: 228, P: 768-770
Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients

DENNIS L. MURPHY
H. KEITH H. BRODIE
WILLIAM E. BUNNEY JUN.
Research08 Jan 1971
Nature

Volume: 229, P: 135-136
Expression of AIDS virus envelope gene in recombinant vaccinia viruses

Shiu-Lok Hu
Steve G. Kosowski
Joel M. Dalrymple
Research10 Apr 1986
Nature

Volume: 320, P: 537-540
Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

Wolkers and colleagues show that the RNA-binding protein ZFP36L2 represses the translation of pre-formed cytokine-encoding mRNAs in memory T cells.

Fiamma Salerno
Sander Engels
Monika C. Wolkers
Research09 Jul 2018
Nature Immunology

Volume: 19, P: 828-837
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
A potent cyclic hexapeptide analogue of somatostatin

Daniel F. Veber
Roger M. Freidinger
Ralph Hirschmann
Research02 Jul 1981
Nature

Volume: 292, P: 55-58
The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions

Jacek Lubkowski
Grzegorz Bujacz
Wlodawer Alexander
Research01 Jan 1997
Nature Structural Biology

Volume: 4, P: 64-69
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a^18H mice

William L. Perry
Carolyn M. Hustad
Neal G. Copeland
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 143-146
Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

Edward Arnold
Alfredo Jacobo-Molina
Stephen H. Hughes
Research07 May 1992
Nature

Volume: 357, P: 85-89
The transcription factor ThPOK suppresses Runx3 and imposes CD4⁺ lineage fate by inducing the SOCS suppressors of cytokine signaling

Lineage fate in the thymus is imposed by the antagonizing effects of the transcription factors ThPOK and Runx3. Park and colleagues show that ThPOK-induced SOCS factors are required for differentiation into the CD4⁺ T cell lineage.

Megan A Luckey
Motoko Y Kimura
Jung-Hyun Park
Research01 Jun 2014
Nature Immunology

Volume: 15, P: 638-645
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

Frederick W. Alt
Naomi Rosenberg
David Baltimore
Research01 Mar 1982
Nature

Volume: 296, P: 325-331
Interferon-gamma is quintessential for NOS2 and COX2 expression in ER^- breast tumors that lead to poor outcome

Robert Y. S. Cheng
Lisa A. Ridnour
David A. Wink
ResearchOpen Access11 May 2023
Cell Death & Disease

Volume: 14, P: 1-12
Reversal of pre-existing NGFR-driven tumor and immune therapy resistance

Dedifferentiation state has been associated with therapy resistance in melanoma. Here, the authors uncover a pre-existing NGFR-expressing, targetable subpopulation that is resistant to immunotherapy and other treatments in melanoma cells and preclinical models.

Julia Boshuizen
David W. Vredevoogd
Daniel S. Peeper
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-13
The Production of Radium from Uranium

FREDERICK SODDY
Research13 May 1909
Nature

Volume: 80, P: 308-309
Possible climatic impact of tropical deforestation

GERALD L. POTTER
HUGH W. ELLSAESSER
FREDERICK M. LUTHER
Research25 Dec 1975
Nature

Volume: 258, P: 697-698
In vivo Complex Formation of Actinomycin D and Deoxyribonucleic Acid

FREDERICK F. BECKER
ANN A. MARGOLIS
WALTER TROLL
Research02 Jul 1966
Nature

Volume: 211, P: 84-85
Pyrrolidone: a Chemical Group of Particular Significance to Differentiation

FREDERICK S. HAMMETT
Research01 Jan 1938
Nature

Volume: 141, P: 82-83
Newborn Polymorphonuclear Leukocyte Aggregation: a Study of Physical Properties and Ultrastructure Using Chemotactic Peptides

Thomas A Olson
Frederick B Ruymann
Paul Jan Thomas
Research01 Dec 1983
Pediatric Research

Volume: 17, P: 993-997
Kinked DNA in crystalline complex with EcoRI endonuclease

Christin A. Frederick
John Grable
John M. Rosenberg
Research24 May 1984
Nature

Volume: 309, P: 327-331

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