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Showing 1–8 of 8 results
Advanced filters: Author: Frederik Verburg Clear advanced filters

  • The speed with which PSMA PET–CT has been adopted for prostate cancer imaging is unprecedented. This technique's clinical value in recurrent disease is uncontested, but its role in initial staging is unclear. Two studies now provide important data on the value of PSMA PET–CT at this management stage.

    • Frederik A. Verburg
    • Andreas Pfestroff
    News & Views
    Nature Reviews Urology
    Volume: 13, P: 498-499

  • Many questions remain about the efficacy of radioiodine treatment for thyroid remnant ablation and therapy of advanced differentiated thyroid cancer. This Review intends to answer some of these questions taking into account novel insights into the treatment and (re)staging of patients with metastatic disease.

    • Christoph Reiners
    • Heribert Hänscheid
    • Frederik A. Verburg
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 589-595

  • The treatment of differentiated thyroid carcinoma (DTC) is currently based on initial staging systems that predict mortality. Recurrence, however, is a much larger problem than mortality in DTC. Tuttle et al. have tested the new American Thyroid Association recurrence risk staging system and found that truly accurate staging requires continuous prognostic re-evaluation according to treatment results.

    • Frederik A. Verburg
    • Christoph Reiners
    News & Views
    Nature Reviews Endocrinology
    Volume: 7, P: 127-128

  • Early attempts at the reinduction of 131I uptake by redifferentiation of 131I-negative differentiated thyroid cancer (DTC) had limited success. Novel therapies targeting the pathways that restore expression of the sodium iodine symporter now offer new hope of success for redifferentiation therapy in DTCs with the BRAFV600E mutation.

    • Frederik A. Verburg
    • Markus Luster
    News & Views
    Nature Reviews Endocrinology
    Volume: 13, P: 9-10

  • TSH-suppressive therapy and the increased risk of cardiovascular disease in patients with differentiated thyroid cancer (DTC) was previously reported. A recent study by Pajamäki and colleagues found that patients with DTC have a higher risk of atrial fibrillation but a lower all-cause cardiovascular death rate. This study offers insights into this effect.

    • Frederik A. Verburg
    • Markus Luster
    News & Views
    Nature Reviews Endocrinology
    Volume: 14, P: 136-137

  • Thyroid ultrasonography is an important element of clinical thyroid diagnostics. Unfortunately, the results of this technique can vary based on the skill and experience of the operator. A new study suggests that assessment of ultrasound images using artificial intelligence has similar sensitivity and improved specificity compared with the judgement of experienced radiologists.

    • Frederik Verburg
    • Christoph Reiners
    News & Views
    Nature Reviews Endocrinology
    Volume: 15, P: 319-321

  • The management of differentiated thyroid cancer (DTC) is undergoing a paradigm shift, with the recognition that personalized therapies might lead to improved outcomes with reduced severity and frequency of complications. In this Review, Markus Luster and colleagues discuss aspects of DTC management that are suitable for individualization, including the extent of surgery, the dosage of131I and the use of levothyroxine. Advances in imaging techniques and the potential benefit of multitargeted kinase inhibitors are also discussed in the context of DTC management.

    • Markus Luster
    • Theresia Weber
    • Frederik A. Verburg
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 563-574