The TCF transcription factor and the co-repressor Groucho form a repressor complex in the absence of Wnt ligand. Here the authors show that during zebrafish gastrulation, the transcription factor Lbx2 enhances Wnt/β-catenin signalling by reducing the interaction between TCF and Groucho.
- Fu-I Lu
- Yong-Hua Sun
- Bernard Thisse