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Showing 1–6 of 6 results
Advanced filters: Author: Fuying Gao Clear advanced filters

  • Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to promote tumor recurrence.

    • Sree Deepthi Muthukrishnan
    • Riki Kawaguchi
    • Harley I. Kornblum
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The cellular function of active DNA demethylation in neurons is not well understood. Here, Song and colleagues show that synaptic activity modulates Tet3 signaling, which in turn regulates glutamatergic synaptic transmission and synaptic scaling. Their work identifies Tet3 as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation.

    • Huimei Yu
    • Yijing Su
    • Hongjun Song
    Research
    Nature Neuroscience
    Volume: 18, P: 836-843

  • SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.

    • Jeremie Vitte
    • Fuying Gao
    • Marco Giovannini
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The transcription factor FOXP2 is the only gene implicated in human speech, and yet it differs very little from the chimpanzee orthologue. Here, the two amino acids specific to humans are shown to alter FOXP2 function in vitro by conferring differential transcriptional regulation, and these observations are extended in vivo to human and chimpanzee brain. Together, these data identify transcriptional targets that may serve critical functions in language development.

    • Genevieve Konopka
    • Jamee M. Bomar
    • Daniel H. Geschwind
    Research
    Nature
    Volume: 462, P: 213-217

  • To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease pathogenesis, the authors profiled mRNA in over 600 brain and peripheral tissue samples from Huntington's disease knock-in mice with increasing CAG repeat lengths. Coexpression network analyses reveal 13 striatal and 5 cortical modules that are highly correlated with CAG length and age.

    • Peter Langfelder
    • Jeffrey P Cantle
    • X William Yang
    Research
    Nature Neuroscience
    Volume: 19, P: 623-633