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Showing 1–3 of 3 results
Advanced filters: Author: Günter Lochnit Clear advanced filters

  • Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

    • Lukas Wettstein
    • Tatjana Weil
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation and higher disease scores in patients with rheumatoid arthritis.

    • Ulrike Steffen
    • Carolien A. Koeleman
    • Georg Schett
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12